Project Grant K23AI195015
- Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $121,182 Project Grant to the University of California, San Diego (UCSD) on December 5, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports research investigating how vaccine formulations influence germinal center dynamics and antibody response development, with completion scheduled for February 3, 2028. This research addresses the critical challenge of...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $2,461,651 to the University of Texas Health Science Center at Houston under the Allergy and Infectious Diseases Research program (CFDA 93.855) on August 18, 2025, for a project extending through July 31, 2029. The project investigates estrogen's impact on immunoglobulin G (IgG) glycomic modulation of immunity and inflammation in people with human immunodeficiency virus (HIV) on antiretroviral...
- Federal Project Grant Award Summary The University of California, San Diego received a $438,500 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective July 8, 2025, through June 30, 2027. The award supports basic immunological research focused on understanding the mechanisms that regulate immunoglobulin gene rearrangement, specifically investigating how enhancers and epigenetic...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant of $184,276 to the University of California, Los Angeles on November 16, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855). This research initiative, titled "The Role of XIST in T Cell Activation and Female-Biased Autoimmunity," will be conducted through June 30, 2027. The project addresses a significant public health gap: approximately...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of California, Los Angeles a $196,020 Project Grant effective July 1, 2026, through June 30, 2031, under the Allergy and Infectious Diseases Research program (CFDA 93.855). This research project will advance fundamental understanding of trained immunity mechanisms driven by interferon gamma (IFNγ), a cytokine critical to innate immune cell memory. The principal...
- Federal Project Grant Award Summary The University of Maryland, Baltimore received a $281,480 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded September 12, 2025, with a completion date of August 31, 2030. This research initiative examines the role of sex hormones and gender-affirming hormone therapy in human papillomavirus (HPV) persistence and immune response among...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of California, San Diego a $3.19 million Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 16, 2025, with a completion date of June 30, 2029. This grant funds investigator-initiated biomedical research examining the roles and regulation of tissue-resident CD8 T cells during persistent viral infection, utilizing the lymphocytic...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $126,460 Project Grant to the University of California, Davis on August 21, 2025, for research investigating the ecological drivers of dysbiosis in the female reproductive tract (FRT). The project, which operates under CFDA 93.855 (Allergy and Infectious Diseases Research) and concludes July 31, 2027, seeks to identify specific host and bacterial metabolic pathways that contribute to...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of California, San Diego a $2.91 million Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) on September 25, 2025, with performance extending through August 31, 2029. The CHROME (Continuum of HIV Response Through Observational Molecular Epidemiology) initiative is a retrospective research study designed to evaluate the impact of public...
- Federal Project Grant Award Summary The University of California, San Francisco received a $182,196 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded June 4, 2026, with completion targeted for May 31, 2028. The project, "Harnessing Antibody-Driven Bioconjugation to Modulate Immune Function," develops novel chemical approaches to modify primary immune cells for...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $198,793 Project Grant to the University of California, San Diego, effective July 1, 2026, through June 30, 2031, under the Allergy and Infectious Diseases Research program (CFDA 93.855). This K23 award supports research investigating how exogenous estradiol affects innate immune responses in people with HIV (PWH) who have an XY karyotype. The project leverages two complementary study cohorts—a longitudinal cohort of 30 XY-PWH sampled before and after estradiol initiation, and a prospective cross-sectional cohort of 40 XY-PWH with and without estradiol exposure—to isolate the effects of estradiol exposure from chromosomal factors on antiviral immunity. Research activities focus on characterizing estradiol-associated differences in plasmacytoid dendritic cells (PDCs) and natural killer (NK) cells across systemic and mucosal compartments using advanced immunologic assays, including high-parameter flow cytometry, cytokine profiling, PDC functional assays, NK cytotoxicity assays, and single-cell RNA sequencing. The project includes mechanistic studies employing Cleavage Under Targets and Release Using Nuclease (CUT&RUN) to map estrogen receptor binding to interferon-related gene promoters, establishing how estradiol exposure regulates NK cell antiviral function and innate immune transcriptional programs in blood and rectal mucosal tissue.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $198.8k | 7/1/26 |