Project Grant R21AI203165
- The National Institute of Allergy and Infectious Diseases awarded The Johns Hopkins University $748,333 on August 14, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to examine interferon-dependent and interferon-independent pathways in systemic lupus erythematosus. The research will classify SLE patients into mechanistically distinct disease subsets based on interferon expression patterns and identify factors that produce an interferon signature independent of...
- The National Institute of Allergy and Infectious Diseases awarded The Feinstein Institutes for Medical Research $209,375 on April 23, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of autophagy in B cell tolerance and its relationship to systemic lupus erythematosus. The research examines how autophagy defects contribute to loss of B cell tolerance in autoimmune disease, specifically exploring crosstalk between autophagy pathways and...
- The National Institute of Allergy and Infectious Diseases awarded the University of Washington $485,375 on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate mechanisms of complement-mediated clearance of extracellular mitochondria released by dying neutrophils. The research explores how neutrophils proteolytically activate complement C3 and deposit it on mitochondria as an opsonin to facilitate their clearance by myeloid cells, thereby...
- The National Institute of Allergy and Infectious Diseases awarded $499,175 to the University of Pittsburgh on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct genetic and functional dissection of tissue-infiltrating and age-associated B cells in murine lupus models. The research aims to identify and characterize pathogenic B cell subsets in systemic lupus erythematosus (SLE), with particular focus on age-associated B cells (ABCs) that...
- The National Institute of Allergy and Infectious Diseases awarded Yale University $462,052 on February 19, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to study ETS2-mediated monocyte activation in systemic lupus erythematosus. The research investigates the role of erythroblast transformation specific 2 (ETS2), a transcription factor, in regulating inflammatory responses in human monocytes and macrophages exposed to lupus immune complexes. The project builds...
- The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, awarded Emory University $100,228 on November 18, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds research into autoreactive, extrafollicular B cell pathways in a TLR7-driven murine model. The project addresses gaps in understanding the origins of extrafollicular effector B cells and the system-wide and microenvironmental signaling that...
- The National Institute of Allergy and Infectious Diseases (NIAID), within the Department of Health and Human Services National Institutes of Health, awarded $165,456 to The Children's Hospital of Philadelphia Research Institute on August 12, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855, Project Grant K08AI203036). The award funds research examining how influenza A virus and hydroxychloroquine shape the presentation of self-antigens in systemic lupus erythematosus...
- The National Institute of Allergy and Infectious Diseases (NIAID), part of the Department of Health and Human Services National Institutes of Health, awarded The Leland Stanford Junior University $127,926 on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to characterize autoreactive B cells and their roles in systemic lupus erythematosus (SLE) pathogenesis using immune organoids. The research investigates how autoreactive B cells transition from a...
- The National Institute of Allergy and Infectious Diseases awarded The University of Texas Southwestern Medical Center $249,000 on June 11, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award, a Project Grant (R21AI199205), funds research into autoreactive T cell and B cell interactions in systemic lupus erythematosus, with work performed in Dallas, Texas through May 31, 2028. The research examines how autoreactive CD4+ T cells and CD8+ T cells interact...
- The National Institute of Allergy and Infectious Diseases awarded La Jolla Institute for Immunology $929,095 on June 2, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to characterize immune cell populations in lymphoid tissue from systemic lupus erythematosus patients and healthy controls using minimally invasive nasal swab sampling combined with flow cytometry and transcriptomic profiling. The research addresses gaps in understanding tissue-specific immune...
The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services National Institutes of Health, awarded The Johns Hopkins University $232,695 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to identify mitochondrial antigens in systemic lupus erythematosus. The research elucidates antigenic targets of anti-whole mitochondria autoantibodies (AWHM) in SLE patients and their contribution to immune-mediated disease amplification. Using an ELISA based on intact, human-derived mitochondria, the researchers detected AWHM in approximately 27 percent of SLE patients, with strong associations to disease activity markers including anti-dsDNA, hypocomplementemia, and upregulated interferon-stimulated genes. The work integrates intact mitochondrial substrates with proteomics and monoclonal antibody generation. Specific aims include defining mitochondrial membrane proteins targeted by AWHM using patient sera and mass spectrometry, followed by validation with recombinant proteins in a longitudinal SLE cohort, and isolating and characterizing monoclonal AWHM from SLE patients' B cells to analyze their specificity and functional properties. Performance occurs in Baltimore, Maryland. The project runs through August 31, 2028. The award is a Project Grant, an assistance type providing funding to research institutions for biomedical research and research training in infectious diseases and related areas.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $232.7k | 8/13/26 |