Project Grant R21AI197044
- Federal Grant Award Summary Yale University received a $373,090 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded August 25, 2025, with completion scheduled for July 31, 2026. The research focuses on developing Modular Degraders of Extracellular Proteins (MODES)—bifunctional small molecules designed to selectively remove pathogenic antibodies and other extracellular proteins...
- Federal Grant Award Summary Yale University received a $837,497 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective May 6, 2025, through April 30, 2030. The grant funds basic science research focused on elucidating the molecular mechanisms by which phosphoinositide 3-kinase gamma (PI3KG) orchestrates antibody responses in B cells. The research deliverables encompass three...
- Federal Grant Award Summary Yale University received a $3.13 million Project Grant from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded July 25, 2025, with a completion date of June 30, 2029. The grant funds investigator-initiated biomedical research focused on elucidating the mechanisms of lymphoid-specific beta-catenin protein degradation in B-lymphoid cells. The research will characterize how B-cells...
- Federal Project Grant Award Summary Yale University received a $2,685,326 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) awarded July 7, 2025, with a completion date of June 30, 2029. The award supports biomedical research investigating the regulation of neutrophil plasticity, heterogeneity, and functional ambivalency by Wnt5 proteins in the context of colitis. The research focuses on...
- Federal Grant Award Summary Yale University received a $251,375 Project Grant award from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855) to identify new antigens in seronegative myasthenia gravis (SNMG). The award, issued September 2, 2025, with completion targeted for August 31, 2027, funds research to identify immune mechanisms underlying SNMG, a subset of myasthenia gravis characterized by the absence of...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded La Jolla Institute for Immunology a Project Grant of $476,436 under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period February 5, 2026 through January 31, 2028. The award supports research to define the function and regulation of ILRUN, a novel Systemic Lupus Erythematosus (SLE)-susceptibility gene identified through genome-wide association studies as...
- Federal Grant Award Summary Yale University received a $2.54 million Project Grant from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855) on September 3, 2025, with completion targeted for August 31, 2029. The award supports fundamental research into novel mechanisms of protein homeostasis mediated by the molecular chaperone DnaK in bacterial cells, with particular emphasis on understanding how this chaperone...
- Federal Grant Award Summary Yale University received a $461,375 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective July 1, 2025 through June 30, 2027. The grant supports systematic identification of molecular interactions between Lyme disease bacteria (Borrelia burgdorferi) and its tick vector (Ixodes scapularis). The primary deliverable involves screening the ISCREAM (I....
- Federal Project Grant Award Summary Yale University received a $3.26 million Project Grant from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period August 1, 2025, through July 31, 2029. The award funds research to elucidate molecular mechanisms of Mycobacterium tuberculosis (MTB) cell envelope assembly, with the goal of identifying drug synergy opportunities to enhance antibiotic efficacy. The...
- Federal Grant Award Summary Yale University received a $4.9 million Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded on July 14, 2025, with a completion date of June 30, 2029. The grant supports biomedical research investigating the mechanistic pathways by which gut microbiota and white adipose tissue control the CD4 T-cell compartment and facilitate T-cell migration from the...
Yale University received a $462,052 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded February 19, 2026, with completion targeted for January 31, 2028. The research, conducted at Yale's New Haven, Connecticut facility, investigates the role of Erythroblast Transformation Specific 2 (ETS2), a transcription factor, in mediating monocyte activation pathways relevant to systemic lupus erythematosus (SLE) pathogenesis. The project examines how lupus immune complexes activate innate immune responses through toll-like receptors and inflammasome pathways, with particular focus on ETS2's contribution to inflammatory cytokine production including interleukin-1 beta, interleukin-6, and interleukin-23. The research deliverables encompass scientific investigations designed to elucidate ETS2-driven inflammatory mechanisms in monocytes and macrophages exposed to lupus-associated immune complexes. This work advances understanding of SLE immunopathogenesis by characterizing transcriptional regulation of inflammatory responses, potentially identifying therapeutic targets for modulating aberrant innate immune activation in autoimmune disease. The project supports basic biomedical research consistent with NIAID's mission to advance knowledge of immunologic and allergic diseases through investigator-initiated research projects evaluated on scientific merit and relevance to public health priorities.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $462.1k | 2/19/26 |