Project Grant K08AI203036
- The National Institute of Allergy and Infectious Diseases awarded The Children's Hospital of Philadelphia $906,255 on July 8, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to discover and characterize novel genes regulating follicular helper T cell function in antibody responses. The research combines variant-to-gene mapping approaches in human follicular helper T cells to identify disease-associated genetic variation influencing B cell antibody responses. Aim...
- The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, awarded Emory University $100,228 on November 18, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds research into autoreactive, extrafollicular B cell pathways in a TLR7-driven murine model. The project addresses gaps in understanding the origins of extrafollicular effector B cells and the system-wide and microenvironmental signaling that...
- The National Institute of Allergy and Infectious Diseases awarded $499,175 to the University of Pittsburgh on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct genetic and functional dissection of tissue-infiltrating and age-associated B cells in murine lupus models. The research aims to identify and characterize pathogenic B cell subsets in systemic lupus erythematosus (SLE), with particular focus on age-associated B cells (ABCs) that...
- The National Institute of Allergy and Infectious Diseases awarded Scripps Research Institute $919,363 on August 17, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the molecular mechanisms governing plasma cell longevity and the establishment of long-lived plasma cells (LLPCs) at mucosal surfaces and bone marrow. The research addresses why current influenza vaccines require annual boosters by examining how plasma cells generated during viral...
- The National Institute of Allergy and Infectious Diseases awarded La Jolla Institute for Immunology $929,095 on June 2, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to characterize immune cell populations in lymphoid tissue from systemic lupus erythematosus patients and healthy controls using minimally invasive nasal swab sampling combined with flow cytometry and transcriptomic profiling. The research addresses gaps in understanding tissue-specific immune...
- The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services National Institutes of Health, awarded The Johns Hopkins University $232,695 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to identify mitochondrial antigens in systemic lupus erythematosus. The research elucidates antigenic targets of anti-whole mitochondria autoantibodies (AWHM) in SLE patients and their contribution to...
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University $480,000 on August 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the molecular mechanisms underlying anti-aquaporin-4 responses in neuromyelitis optica spectrum disorder (NMOSD). The research addresses the autoimmune pathogenesis of NMOSD, a severe central nervous system disease driven by T cell and autoantibody responses against aquaporin-4 on...
- The National Institute of Allergy and Infectious Diseases awarded The Feinstein Institutes for Medical Research $209,375 on April 23, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of autophagy in B cell tolerance and its relationship to systemic lupus erythematosus. The research examines how autophagy defects contribute to loss of B cell tolerance in autoimmune disease, specifically exploring crosstalk between autophagy pathways and...
- The National Institute of Allergy and Infectious Diseases awarded The Johns Hopkins University $748,333 on August 14, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to examine interferon-dependent and interferon-independent pathways in systemic lupus erythematosus. The research will classify SLE patients into mechanistically distinct disease subsets based on interferon expression patterns and identify factors that produce an interferon signature independent of...
- The National Institute of Allergy and Infectious Diseases (NIAID), part of the Department of Health and Human Services National Institutes of Health, awarded The Leland Stanford Junior University $127,926 on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to characterize autoreactive B cells and their roles in systemic lupus erythematosus (SLE) pathogenesis using immune organoids. The research investigates how autoreactive B cells transition from a...
The National Institute of Allergy and Infectious Diseases (NIAID), within the Department of Health and Human Services National Institutes of Health, awarded $165,456 to The Children's Hospital of Philadelphia Research Institute on August 12, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855, Project Grant K08AI203036). The award funds research examining how influenza A virus and hydroxychloroquine shape the presentation of self-antigens in systemic lupus erythematosus (SLE). The project investigates altered antigen presentation by major histocompatibility complex class II, a mechanism implicated in SLE pathogenesis. The central hypothesis holds that influenza A virus manipulates endogenous processing pathways to alter the self-immunopeptidome and promote autoimmunity, while hydroxychloroquine's therapeutic effects result from inhibiting these same pathways. Aim 1 uses detailed pathway mapping to identify endogenous MHC II processing pathways required for influenza-induced self-peptide presentation and targeted by hydroxychloroquine. Aim 2 connects changes in autoantigen presentation to clinical disease by determining the impact of influenza infection and hydroxychloroquine treatment on the self-immunopeptidome and autoimmune responses in lupus-prone B6.SLE123 mice. The project period runs from August 12, 2026, through July 31, 2031, with performance at Philadelphia, Pennsylvania.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $165.5k | 8/12/26 |