Project Grant F32AI191486
- The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, awarded the Trustees of Indiana University $129,915 on December 29, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research characterizing the binding interaction between Coxsackievirus B3 (CVB3) and enteric bacteria. CVB3 is an enteric virus that causes viral myocarditis and other serious infections. The research addresses a gap in...
- The National Institute of Allergy and Infectious Diseases awarded the Trustees of Indiana University $658,213 on July 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how chronic viral infections suppress dendritic cell function and impair secondary immune responses. The research examines mechanisms by which persistent viral infections such as HIV and hepatitis B and C alter CD8 T cell priming through decreased dendritic cell activation. The...
- The National Institute of Allergy and Infectious Diseases awarded Temple University $237,749 on August 5, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop risk prediction tools for severe vibriosis outcomes by integrating patient-level and county-level epidemiological data. The project will address gaps in current vibrio infection risk assessment by analyzing individual-level CDC surveillance data from COVIS (nationwide passive surveillance) and FoodNet...
- The National Institute of Allergy and Infectious Diseases awarded the University of Florida $741,023 on June 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop VIGOR, a satellite-based public health forecasting system for predicting Vibrio species infection risk in coastal regions. The project addresses pathogenic Vibrio species—including V. vulnificus, V. parahaemolyticus, and V. alginolyticus—that proliferate in seawater under conditions influenced...
- The National Institute of Allergy and Infectious Diseases awarded Trustees of Indiana University $435,875 on June 9, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop methods for assessing gene function in Culicoides biting midges and test RNA interference–based insect gene silencing as a control mechanism for these disease vectors. The research will evaluate interfering RNA produced and delivered in Saccharomyces cerevisiae yeast to silence genes in...
- The National Institute of Allergy and Infectious Diseases awarded the Trustees of Indiana University $370,835 on August 18, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop a computational framework for analyzing HIV immune escape across viral diversity. The funded research addresses a critical gap in HIV immunology: the lack of a rigorous computational approach capable of distinguishing universal, robust escape mechanisms from noise caused by...
- The National Institute of Allergy and Infectious Diseases awarded the Trustees of Indiana University $710,142 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on CD4 TH1 cell restoration for control of chronic viral infections. The project, awarded as a Project Grant (R01AI190033), runs through August 31, 2031, with place of performance in Indianapolis, Indiana. The research addresses T cell exhaustion driven by prolonged...
- The National Institute of Allergy and Infectious Diseases awarded Trustees of Indiana University (doing business as Indiana University) $617,374 on August 7, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to define nuclear pore complex subsets and import pathways that regulate HIV-1 integration and gene expression. The research will characterize how HIV-1 exploits nuclear pore complex remodeling and host factors to gain access to the nucleus in non-dividing cells,...
- The National Institute of Allergy and Infectious Diseases awarded $435,875 to Trustees of Indiana University (Indiana University Indianapolis) on July 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how Chlamydia-infected cells affect non-infected bystander host cells and identify intervention points that could promote clearance of Chlamydia trachomatis without broad-spectrum antibiotics. The research addresses the mechanisms underlying...
- The National Institute of Allergy and Infectious Diseases awarded $435,875 to Trustees of Indiana University (doing business as Indiana University Indianapolis) on April 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to fund experimental evolution research examining how gut-adapted mutations in Klebsiella pneumoniae affect bacterial pathogenesis and infection dynamics. The research uses an experimental evolution approach to determine how evolutionary adaptation...
The National Institute of Allergy and Infectious Diseases awarded the Trustees of Indiana University $153,560 on October 16, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research on bacterial signaling in inter-species Vibrio interactions during host-colonization stages. The research investigates mechanisms of multi-species bacterial interactions and their impact on host colonization and disease incidence in Vibrio communities. Vibrio species are significant environmental human pathogens in aquatic and marine environments that cause vibriosis disease, including gastroenteritis, necrotizing fasciitis, and sepsis. Transmission occurs through consumption of raw shellfish or exposure of open wounds to seawater. The study examines quorum sensing and bacterial signaling between Vibrio species in mixed communities to understand pathogenesis mechanisms, addressing the gap between existing single-species culture studies and natural multi-species environments where Vibrio bacteria exist in heterogeneous microbial communities on marine snow. Environmental changes are expanding Vibrio's geographic range and increasing human infection rates, making understanding of multi-species transmission mechanisms urgent. Place of performance is Bloomington, Indiana. The period of performance extends from October 16, 2026, through April 30, 2029. This is a project grant, the assistance type supporting research at public and nonprofit institutions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 4/17/26 | ||
| Not listed | $76.8k | 4/17/26 | ||
| Not listed | $76.8k | 4/17/26 |