Project Grant R01AI192676
- The National Institute of Allergy and Infectious Diseases awarded Whitehead Institute for Biomedical Research $899,850 on February 20, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how apicomplexan parasites recognize and invade host cells. The funded research examines the molecular mechanisms by which parasites such as Toxoplasma and Plasmodium trigger rhoptry discharge—the secretion of proteins from specialized organelles upon contact with host...
- The National Institute of Allergy and Infectious Diseases awarded the University of Pittsburgh $718,028 on June 9, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research deciphering the gating mechanism of intraflagellar transport in Trypanosoma brucei, a parasitic protozoan responsible for African trypanosomiasis. The research will characterize the transition zone, a gating structure at the flagellar base that controls intraflagellar transport complex...
- The National Institute of Allergy and Infectious Diseases awarded the University of California, San Diego $480,000 on September 16, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the molecular basis for arboviral fitness in vector and reservoir hosts. The research examines how arboviruses replicate across evolutionarily distant hosts—insects and vertebrates—despite showing high specificity in their transmission cycles. Using alphaviruses as a...
- The National Institute of Allergy and Infectious Diseases awarded The Pennsylvania State University $247,000 on May 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to study mechanisms of translational repression release in Plasmodium parasites during transmission from mammals to mosquito vectors. The research applies reverse genetic, transcriptomic, proteomic, and microscopy-based approaches to determine how malaria parasites control gene expression before and...
- The National Institute of Allergy and Infectious Diseases awarded $147,280 to the University of Pennsylvania on January 23, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate T cell trafficking mechanisms in cryptosporidium infection. The funded research examines how T cells migrate to the small intestine to control cryptosporidium, an apicomplexan parasite causing diarrhea and death in immunocompromised individuals and malnourished children globally....
- The National Institute of Allergy and Infectious Diseases awarded $157,500 to the University of California, Los Angeles on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support basic research on the structure and ligand binding of receptor adenylate cyclase from Trypanosoma brucei, a flagellated eukaryotic parasite responsible for African trypanosomiasis. The research examines cAMP signaling pathways in T. brucei, focusing on receptor-type adenylate...
- The National Institute of Allergy and Infectious Diseases awarded Kansas State University $738,183 on July 20, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to characterize the immunoregulatory protease network that controls melanization in Anopheles gambiae, the African malaria mosquito vector. The research identifies molecular interactions that regulate phenoloxidase activation and melanization cascade proteases, with the objective of understanding how protease...
- The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, awarded The Pennsylvania State University $235,950 on May 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on engineering artificial endosymbiosis in mosquitoes using synthetic biology. The project addresses fundamental gaps in understanding obligate endosymbionts—microorganisms living within eukaryotic host cells—and their potential...
- The National Institute of Allergy and Infectious Diseases awarded New Mexico State University $146,671 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on September 3, 2026, for a project grant (R16AI201108) investigating the link between immunometabolism and epigenetics in the malaria vector mosquito Anopheles stephensi. The project employs a multi-omics approach integrating metabolomic, epigenomic, and transcriptomic data to establish mechanistic linkages between...
- The National Institute of Allergy and Infectious Diseases awarded The Johns Hopkins University $765,422 on April 17, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research on mechanisms of antigen diversification in Trypanosoma brucei. The research investigates how T. brucei, an extracellular protozoan parasite endemic to sub-Saharan Africa, evades host antibody clearance through periodic switching of its variant surface glycoprotein (VSG) coat. The...
The National Institute of Allergy and Infectious Diseases awarded Villanova University $513,445 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how the flagellum organizes cAMP signaling, attachment, and differentiation in kinetoplastid parasites. The funded research examines fundamental mechanisms of parasite adaptation and transmission. Kinetoplastid parasites undergo dramatic morphological and functional changes as they transition between host niches and prepare for transmission to insect vectors. The flagellum acts as a spatial regulator of signal transduction cascades that may drive these differentiation events. The award supports investigation of an underexplored hemidesmosome-like attachment structure that forms between the parasite flagellum and insect surfaces. This attachment appears crucial for insect colonization and differentiation to infectious forms, yet the signals controlling attachment and its connection to differentiation remain poorly understood. The research uses the mosquito parasite Crithidia fasciculata as a model system. Swimming cells readily adhere in vitro to artificial substrates, forming attachments indistinguishable from those observed in vivo. Surface contact triggers morphological changes including flagellar shortening, cell rounding, and gene expression shifts consistent with cell fate changes. The investigator has developed and standardized assay conditions permitting time-lapse studies and quantitation to address these questions genetically and pharmacologically. The period of performance runs from September 1, 2026, through August 31, 2031. Performance takes place in Villanova, Pennsylvania.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $513.4k | 9/1/26 |