Project Grant R01AI190189
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $204,347 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the University of Vermont & State Agricultural College to study the intracellular colonization strategies of Salmonella enterica serovar Typhimurium within human intestinal epithelial cells and macrophages. The research aims to characterize bacterial and host transcripts during Salmonella infection, distinguish between cytosolic and...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $131,076 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Leland Stanford Junior University. The grant will fund research to systematically understand how evolutionary pressures from the human host and bacteriophages contribute to the genetic diversity of the Salmonella enterica pathogen. Key goals include expanding upon the grantee's established random barcoded transposon...
- The Project Grant award of $197,646 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), supports research to enhance the function of bacteriophages (viruses that attack bacteria) as a potential treatment for antimicrobial resistant bacterial infections. The award recipient, the University of California, San Diego (UCSD), will conduct experimental evolution studies to identify genetic...
- This Project Grant award of $219,122 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research on the novel regulation of gene expression in the food-borne pathogen Salmonella typhimurium. The research aims to understand how small regulatory RNAs (sRNAs) interact with the 3' untranslated region of the hild mRNA to control its stability, which in turn regulates the Type 3 Secretion System...
- The University of Utah was awarded a $728,244 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on the molecular mechanisms of Salmonella's type III secretion system. The goal is to develop a better understanding of how this critical virulence mechanism in Gram-negative pathogens, including Salmonella, Shigella, Vibrio, Pseudomonas, Yersinia, and Chlamydia, selects...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand how the human-adapted Salmonella enterica serovar Typhi (S. Typhi) pathogen activates the Integrated Stress Response (ISR) in host macrophages and how this impacts the innate immune response and infection outcomes. The $173,416 grant, awarded on January 18, 2025, will fund the...
- The National Science Foundation awarded a two-year, $138,000 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to conduct research characterizing the genetic mechanisms of bacteria-phage coevolution in Listeria and Salmonella. The postdoctoral fellow will analyze the dynamic relationships between the foodborne pathogens Listeria monocytogenes and Salmonella enterica, and their bacteriophages. Through serial passaging experiments and whole genome sequencing, the...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research (CFDA 93.855) program, is supporting research to investigate the role of the protein synaptopodin during bacterial infection by Shigella flexneri. The $2,637,034 award to the University of Colorado-Denver aims to examine how synaptopodin contributes to the spread of S. flexneri and other intracellular pathogens between host cells. The research...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $142,492 Project Grant under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) to The Washington University in Missouri. The grant, titled "High Throughput Identification of Bacteriophages and Their Hosts with Single-Cell Transcriptomics," aims to establish an innovative, high-throughput phage-host pairing tool for rapidly screening complex, naturally occurring microbial...
- This federal Project Grant award of $408,375.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Oregon State University (OSU). The award will fund research to deepen the understanding of phage biology and its interaction with Mycobacterium abscessus (MAB) bacteria, a clinically important pathogen associated with high morbidity and fatality rates. The goal is to apply this knowledge to...
This federal Project Grant award of $2,727,148.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research on the interactions between bacteriophages (phages) and the Salmonella pathogen during oxidative stress. The goal is to characterize the mechanisms by which the Salmonella pathogen senses oxidative stress, and how this leads to the activation of phage-derived enzymes that inhibit the pathogen. The research will be conducted by the University of Colorado-Denver over a period of 4 years, from September 2025 to August 2029. The findings are expected to advance the understanding of host-pathogen interactions and potentially inform the development of new antimicrobial strategies against Salmonella infections.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.7m | 9/3/25 |