Federal Project Grant Summary: PRIME-HIV

The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Johns Hopkins University a Project Grant totaling $426,823 (awarded June 3, 2026; completion May 31, 2028) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop and evaluate PRISM-HIV, an artificial intelligence-driven, case-based learning platform for continuing medical education in HIV medicine. The project extends prior work on PRISM (Precision Review and Interactive Simulation in Medicine), a large language model-based educational tool, by creating an interactive clinical learning system that simulates faculty-led case discussions and diagnostic feedback. PRISM-HIV is designed to deliver personalized, scalable medical education aligned with the Foundations in HIV Medicine curriculum and targets medical residents, general internists, and advanced practice providers who require enhanced training in HIV medicine to address the documented shortage of skilled HIV clinicians in the United States.

The primary deliverable is a functional AI-powered educational platform that guides learners through interactive HIV case scenarios, promotes clinical reasoning development, provides precision-targeted review content, and assesses user performance. By leveraging large language model technology to simulate expert clinical instruction, PRISM-HIV addresses a critical gap in continuing medical education—scaling case-based and flipped-classroom learning approaches that traditionally require intensive faculty resources. The project directly supports the NIH's research objective to strengthen the HIV clinical workforce through innovative educational tools that improve clinician confidence and competency in HIV care management.