Project Grant R21AI195096
- This $698,349 Project Grant awarded on February 25, 2025 by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports the development of an "Integrated Multiplexed Diagnostic Assay Targeting Fusion Lipoproteins and Cardiolipin for Detection of Treponemal and Nontreponemal Antibodies in Syphilis Patients." The goal is to create a rapid, point-of-care diagnostic test that can definitively diagnose...
- This Project Grant award of $448,150 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to explore how the syphilis-causing bacterium Treponema pallidum avoids complement-mediated killing by recruiting the human complement inhibitor Factor H. The goal is to improve understanding of syphilis pathogenesis and identify new control strategies, as syphilis remains a public health concern...
- This Project Grant award of $418,360.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Program (CFDA 93.855), aims to systematically analyze Treponema pallidum gene expression under host infection-related conditions. The central hypothesis is that T. pallidum, the bacterium that causes syphilis, alters its gene expression in response to changes in oxygen concentration, temperature, and host interactions, which enables...
- This federal Project Grant award of $283,694 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research by Dalhousie University to investigate how the syphilis bacterium, Treponema pallidum, interacts with the cervicovaginal epithelial barrier and whether the vaginal microbiome influences susceptibility to T. pallidum infection. The research aims to advance the understanding of syphilis transmission dynamics and...
- This Cooperative Agreement award from the National Science Foundation (CFDA 47.084 - NSF Technology, Innovation, and Partnerships) provides $1,250,000 in funding to Prompt Diagnostics, Inc. for the development of an automated point-of-care diagnostic test for infections caused by Treponema pallidum (syphilis). The project aims to create the first all-in-one diagnostic device that can rapidly and accurately detect syphilis infections in decentralized settings, enabling faster therapeutic...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $243,235 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Johns Hopkins University. This grant will fund the development and validation of direct-from-sample whole genome sequencing methods for Neisseria gonorrhoeae (NG) to support expanded genomic surveillance of NG and other bacterial sexually transmitted infections in populations with high HIV burdens in Eastern and...
- The University of Washington was awarded a $485,375 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant, awarded on August 11, 2025, will fund research to elucidate the role of genetic recombination in Treponema pallidum, the bacterium that causes syphilis. Specifically, the researchers will investigate the mechanisms of homologous recombination in T. pallidum and examine...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $451,956 Project Grant on August 15, 2025 to Baylor College of Medicine under the Allergy and Infectious Diseases Research program (CFDA 93.855) to study the mechanisms by which the syphilis-causing bacterium Treponema pallidum invades and impacts the placenta. The project aims to use novel in vitro models of trophoblast cells and organoids to characterize T. pallidum attachment, growth, and internalization, as well as...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded Baebies, Inc., a $1,600,723 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop a rapid, point-of-care diagnostic test to identify viable sexually transmitted infections (STIs). The project aims to create a panel of novel STI viability PCR (V-PCR) assays that can differentiate active infection from resolved, non-viable infections. This solution will utilize digital microfluidic...
- This federal Project Grant award of $445,250.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to establish a mouse model of congenital syphilis (CS) and determine changes in the host immune response. The primary goals are to lay the foundation for developing improved diagnostics and vaccines for syphilis, a sexually transmitted disease with increasing global incidence. The grant, awarded to...
This federal Project Grant award of $426,625.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to assess the feasibility of using the Dual Path Platform (DPP) Syphilis TNT assay for the longitudinal evaluation of syphilis treatment response and reinfection. The project, titled "Quantitative Assessment of the DPP Syphilis TNT Assay in Infection and Treatment Response", will be conducted by The Johns Hopkins University from August 7, 2025 to July 31, 2027. The key products or services to be delivered under this grant include a quantitative assessment of the DPP Syphilis TNT assay's performance in diagnosing syphilis, monitoring treatment response, and detecting reinfection, which could lead to the development of improved syphilis diagnostic and monitoring tools.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $426.6k | 8/6/25 |