Project Grant R21AI199686
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Broad Institute, Inc. a Project Grant totaling $481,250 under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period August 1, 2025, through July 31, 2027. The award supports the development of novel antimicrobial compounds based on induced proximity principles. The project involves the design and creation of chimeric molecules that combine binders of...
- Federal Project Grant Award Summary The Broad Institute of MIT and Harvard received a $165,269 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded June 12, 2026, with a completion date of May 31, 2028. The award funds research directed toward developing HIV-1 broadly neutralizing antibodies (BNAbs) by engineering common human antibody precursors to target the V2 apex epitope of...
- Project Grant Summary Brigham and Women's Hospital received a $198,630 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 1, 2025, through July 31, 2030. This award supports the development and validation of BADLOCK, a CRISPR-based diagnostic assay designed to rapidly identify bacterial species and antimicrobial resistance (AMR) genes from blood cultures in...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant of $227,076 to Harvard Medical School under the Allergy and Infectious Diseases Research program (CFDA 93.855) on September 3, 2025, for performance through August 31, 2027. This research initiative investigates the mycomembrane protein assembly pathway in Mycobacteriales bacterial species, with the objective of identifying novel therapeutic targets to combat rising antimicrobial...
- Federal Grant Award Summary Funding Agency: National Institute of Allergy and Infectious Diseases (NIAID) Program: Allergy and Infectious Diseases Research (CFDA 93.855) Award Amount: $463,375 Award Date: February 2, 2026 Project Period: February 2, 2026 – January 31, 2028 Harvard College's Office for Sponsored Programs is conducting high-throughput screening research to discover novel antimicrobial metabolites produced by human gut bacteria that contribute to colonization resistance—the...
- Federal Grant Award Summary Brigham & Women's Hospital Inc., Department of Faulkner Pathology, received a $171,046 Project Grant from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period April 1, 2026 through March 31, 2031. The award supports research and career development activities led by Dr. Basta to develop a transposon-based gene drive (TNDRIVE) technology designed to combat antimicrobial...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Boston Children's Hospital $151,040 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on December 4, 2025, to support a project extending through July 31, 2028. This Project Grant funds basic science research investigating the regulatory mechanisms of a small regulatory RNA (sRNA) designated BECO in Pseudomonas aeruginosa, a gram-negative bacterium that causes serious...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Massachusetts General Hospital a $453,750 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective August 1, 2025, through July 31, 2027. The award funds research investigating neutrophil swarming mechanisms in response to Pseudomonas aeruginosa microcolony aggregates. The research will develop an ex vivo model to elucidate the cellular and molecular...
- Federal Grant Award Summary Harvard Medical School received a $253,500 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective May 21, 2026, with a completion date of April 30, 2028. This award supports fundamental research investigating a novel eukaryotic-like uridyltransferase enzyme designated NagU in Staphylococcus aureus, with the objective of understanding how this enzyme...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Massachusetts a $412,581 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective August 1, 2025, through July 31, 2027. This research initiative focuses on investigating specialized mitochondrial deoxyribonucleic acid (DNA) polymerases in African trypanosomes to advance understanding of kinetoplast DNA (kDNA) replication mechanisms....
The Broad Institute of MIT and Harvard received a $480,650 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded on June 11, 2026, with completion scheduled for May 31, 2028. The award funds a genome-wide association study (GWAS) designed to uncover genetic determinants of carbapenem resistance in Klebsiella pneumoniae, a pathogen representing an urgent global health threat due to high mortality rates and increasing prevalence. The research will address critical knowledge gaps regarding resistance mechanisms by analyzing an expanded dataset of publicly available K. pneumoniae genomes using reference-free GWAS methodology with unitigs, employing quantitative minimum inhibitory concentration (MIC) phenotyping to enhance statistical detection of genetic variants with subtle effects on meropenem resistance, and conducting experimental validation of candidate causal variants across more than 100 isolates sourced from geographically diverse regions. The deliverables encompass comprehensive genomic analysis, identification of novel genetic variants associated with carbapenem resistance, experimental validation studies reducing false positives from linkage disequilibrium, and the generation of scientific knowledge to advance understanding of resistance mechanisms in this clinically important pathogen. Research performance will be conducted at the Broad Institute's Cambridge, Massachusetts facility.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $480.7k | 6/12/26 |