Project Grant K99AI190054
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant of $111,513 under the Allergy and Infectious Diseases Research program (CFDA 93.855) to President and Fellows of Harvard College, doing business as Harvard Medical School, on January 18, 2025. The grant supports research to investigate how gram-positive bacteria use the nucleotide second messenger cyclic-di-AMP to monitor and respond to defects in the cell envelope. The research aims to understand the...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $637,729 to President and Fellows of Harvard College (doing business as Harvard Medical School) from December 13, 2024 to November 30, 2029. The funding supports research to investigate the molecular mechanisms underlying the activation and regulation of essential bacterial cell wall synthase enzymes, with...
- This $193,375 Project Grant, awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to identify bacterial determinants that may contribute to variable treatment responses for tuberculosis (TB). The project, conducted by researchers at the Harvard T.H. Chan School of Public Health, aims to investigate the effects of clinically prevalent variants in the ESX1 secretion system on TB...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant of $137,286 to President and Fellows of Harvard College, doing business as Harvard Medical School, under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The grant supports research to investigate a novel phospholipase enzyme, PLPD, and its role in maintaining the asymmetric outer membrane barrier of the human pathogen Pseudomonas aeruginosa. The project aims to develop...
- This federal Project Grant award for $711,993.00, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research to examine the effects of Mycobacterium tuberculosis (MTB) disease on HIV-1 pathogenesis in people living with HIV (PWH). The research aims to assess how MTB disease influences the development of broadly neutralizing HIV-1 antibodies, the emergence of NAb-resistant viral...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $749,417 to President and Fellows of Harvard College to develop novel antibiotic candidates that target the lipoprotein transport pathway in Gram-negative bacteria. The research aims to synthesize and evaluate a modular platform of antibiotics with improved potency and optimized...
- This $811,396 Project Grant, awarded by the National Institute of Allergy and Infectious Diseases under CFDA 93.855 Allergy and Infectious Diseases Research, is focused on understanding the mechanisms of lipid/metabolite and drug transport in Mycobacterium tuberculosis and related mycobacteria. The major objectives are to establish the molecular mechanisms and structures of three specific MMPL transporter proteins and their complexes with interacting partner proteins. Key activities include...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $325,806 to support 8 second- and third-year students in the Harvard Graduate Program in Bacteriology (GPIB) T32 training program. The overarching goal is to teach students to identify important biological questions and cultivate the skills to answer them. The program provides foundational and quantitative...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $3,262,539 to Yale University to elucidate the molecular mechanisms underlying the assembly of the mycobacterial cell envelope, a critical barrier to antibiotics. The research aims to investigate the synthesis and transport of mycolic acids, the function of an essential efflux pump, and the regulation of mycomembrane biosynthesis. These studies...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), is providing $130,932.00 to support research on the molecular mechanisms underlying the activation and regulation of the inflammasome executioner protein gasdermin D (GSDMD). The research aims to elucidate the processes of GSDMD pore formation and membrane rupture, which are critical for the inflammatory...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is providing $125,901 to Harvard Medical School to investigate the mechanism by which certain outer membrane proteins in mycobacterial species are transported and assembled. The goal is to understand this process, which is critical for the integrity of the bacterial cell envelope and could lead to new antimicrobial therapies. The research involves validating binding interactions between the transport enzymes, called mycoloyltransferases, and the outer membrane proteins, as well as using a cell-based assay to test the hypothesis that the mycoloyltransferases facilitate transport of these proteins across the cell envelope. This 2-year project began on September 3, 2025 and is expected to be completed by August 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $125.9k | 9/3/25 |