Project Grant R21AI193788
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $451,956 Project Grant on August 15, 2025 to Baylor College of Medicine under the Allergy and Infectious Diseases Research program (CFDA 93.855) to study the mechanisms by which the syphilis-causing bacterium Treponema pallidum invades and impacts the placenta. The project aims to use novel in vitro models of trophoblast cells and organoids to characterize T. pallidum attachment, growth, and internalization, as well as...
- This federal Project Grant award of $283,694 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research by Dalhousie University to investigate how the syphilis bacterium, Treponema pallidum, interacts with the cervicovaginal epithelial barrier and whether the vaginal microbiome influences susceptibility to T. pallidum infection. The research aims to advance the understanding of syphilis transmission dynamics and...
- This $698,349 Project Grant awarded on February 25, 2025 by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports the development of an "Integrated Multiplexed Diagnostic Assay Targeting Fusion Lipoproteins and Cardiolipin for Detection of Treponemal and Nontreponemal Antibodies in Syphilis Patients." The goal is to create a rapid, point-of-care diagnostic test that can definitively diagnose...
- This Project Grant award of $418,360.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Program (CFDA 93.855), aims to systematically analyze Treponema pallidum gene expression under host infection-related conditions. The central hypothesis is that T. pallidum, the bacterium that causes syphilis, alters its gene expression in response to changes in oxygen concentration, temperature, and host interactions, which enables...
- The University of Connecticut Health Center (UCHC) was awarded a $457,875 Project Grant by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate fundamental aspects of syphilis disease pathogenesis, including nutrient acquisition and environmental sensing by the bacteria Treponema pallidum. The grant, which spans from August 1, 2025 to July 31, 2027, will support research activities to...
- This Project Grant award of $448,150 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to explore how the syphilis-causing bacterium Treponema pallidum avoids complement-mediated killing by recruiting the human complement inhibitor Factor H. The goal is to improve understanding of syphilis pathogenesis and identify new control strategies, as syphilis remains a public health concern...
- The University of Washington was awarded a $485,375 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant, awarded on August 11, 2025, will fund research to elucidate the role of genetic recombination in Treponema pallidum, the bacterium that causes syphilis. Specifically, the researchers will investigate the mechanisms of homologous recombination in T. pallidum and examine...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $466,725 Project Grant under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) to the University of South Carolina (UEI J22LNTMEDP73). The grant aims to enhance the utility of deer mice as an infectious disease model by: 1) strengthening the breeding capacities of the university's Peromyscus Genetic Stock Center, 2) developing Peromyscus-specific antibodies, and 3) curating electronic...
- The University of California, Los Angeles (UCLA) was awarded a $627,699 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) to conduct a randomized clinical trial to prevent maternal syphilis and congenital syphilis in Rio de Janeiro, Brazil. The project aims to evaluate the use of enhanced serologic screening and point-of-care treponemal testing during prenatal care to address...
- This $1,649,910 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will fund a research project at Tufts University School of Medicine to study the immune response to tick-transmitted spotted fever rickettsiosis. The project aims to utilize a guinea pig animal model to differentiate the immune responses to three different spotted fever group Rickettsia species that vary in their ability to cause human...
This federal Project Grant award of $445,250.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to establish a mouse model of congenital syphilis (CS) and determine changes in the host immune response. The primary goals are to lay the foundation for developing improved diagnostics and vaccines for syphilis, a sexually transmitted disease with increasing global incidence. The grant, awarded to Rutgers, The State University of New Jersey, will support research to assess pathogen persistence and the host response to Treponema pallidum, the bacterium that causes syphilis, in the newly developed mouse model of CS. This project builds on the researchers' prior work, including the identification of a placental cell binding adhesin and testing of vaccine candidates against syphilis in a rabbit infection model. The award period runs from August 6, 2025, through July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $445.3k | 8/6/25 |