This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $175,000 to the La Jolla Institute for Immunology to study the role of Alternaria fungal sensitization in asthma pathogenesis. The research aims to determine the association between Alternaria-specific T cells and protection against Alternaria sensitization, as well as identify Alternaria-specific T cell...
This Project Grant award of $597,904, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support a comprehensive analysis of the impact of the infant microbiome and its interactions with host genetics on childhood asthma risk. The researchers at the University of Wisconsin-Madison will develop novel statistical methods to: (1) detect associations between the infant microbiome and host...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $936,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Colorado-Denver. The 5-year grant, which commenced on August 12, 2024, will support research to elucidate the regulation and function of tissue-resident eosinophils in allergic microenvironments. The project aims to 1) target cell cycle machinery to manipulate eosinophil specialization, 2) delineate pre-...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $207,500 to the University of Southern California to study the role of the MIF/CD74 pathway in group 2 innate lymphoid cells (ILC2) and its impact on airway hyperreactivity and asthma. The key objectives of this 2-year research project are to: 1) Assess the expression patterns of CD74 in the lungs and measure...
The federal Project Grant award R56AI192629 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) federal grant program. The $250,000 award to The General Hospital Corporation (doing business as Massachusetts General Hospital) aims to identify key pathways that mediate the survival and maintenance of lung-resident memory T helper type 2 (Th2) cells in allergic asthma. The research seeks to determine if...
This Cooperative Agreement award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), provides $2,606,605.00 in funding to National Jewish Health over a period of approximately 5 years starting on September 6, 2024. The award supports research to decipher the role of early-life skin dysfunction in the development of the "allergic march" - the sequential progression from atopic...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $732,225 to investigate the role of mitochondrial DNA (mtDNA) variants in the pathogenesis of asthma. The research aims to: 1) identify associations between mtDNA single nucleotide variants (SNVs) and asthma risk/traits, and examine how risk variants influence mitochondrial function in cells from asthmatic and healthy individuals, and 2)...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $453,750 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The General Hospital Corporation (doing business as Massachusetts General Hospital) to establish a CRISPR-based airway organoid platform for screening mechanisms involved in airway epithelial cell and intraepithelial airway macrophage interactions. The goal is to identify novel mediators of airway immune cell homeostasis,...
This Project Grant award, valued at $730,392, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The funding supports research conducted by the University of Colorado-Denver to investigate the role of adipose tissue and eosinophils in regulating airway function and inflammation in lean and obese mice. Specifically, the research aims to determine: 1) the metabolic response of adipose tissue to...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $689,068 Project Grant under CFDA 93.855 Allergy and Infectious Diseases Research to the University of Cincinnati to establish ex vivo growth systems for the fungal genus Pneumocystis. The key objectives are to: 1) conduct metabolite profiling and flux balance analysis to identify critical nutrients for growth of the P. carinii surrogate in a cell-free culture system, and 2) develop rat and human alveolar organoids to...