This federal Project Grant award of $508,500.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports a study titled "BREATH - Breastfeeding, Early-Life Microbiome and Respiratory Health Study" at New York University School of Medicine. The research aims to elucidate the intricate relationships between breastfeeding, infant microbiome development, and early-life respiratory health...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $816,358 to Vanderbilt University Medical Center (VUMC) to conduct research on the effects of infant antibiotic exposure on the development of the early-life airway and gut microbiome, and the associated risk of childhood asthma. The goals of this 5-year project are to: 1) determine the age when infants are most susceptible to the harmful...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $175,000.00 to the La Jolla Institute for Immunology to conduct research on the role of Alternaria fungal sensitization in asthma pathogenesis. The key research objectives are to: Determine the association between Alternaria-specific T cell subsets, including a novel "THIFNR" cell population, and protection...
This $242,310 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to understand how the commensal microbiota are trafficked to the thymus and presented to developing T cells during early life. The research aims to elucidate the mechanisms by which the intestinal environment and maternal antibodies selectively filter and transport specific commensal antigens to...
The National Institute of Child Health and Human Development (NICHD) awarded a $171,728 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to Weill Medical College of Cornell University to study the role of premature infant gut microbiome dysbiosis in mediating immune development and response to respiratory syncytial virus (RSV) infection. The research aims to define how the altered gut microbiome in premature infants impacts their ability to mount effective...
This federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to leverage metagenomic next-generation sequencing (MNGS) to study pathogen transmission and antimicrobial resistance (AMR) gene dynamics in a neonatal intensive care unit (NICU) setting. The $197,748 award to The Regents of the University of California, San Francisco will support the following key research...
This federal Project Grant award, totaling $249,000.00, was provided by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The award supports the development of methodologies to reveal the role of the blood microbiome in the gut-lung axis for asthma pathogenesis. The project aims to develop a strain-resolved computational pipeline for reduced metagenomic sequencing to profile the blood microbiome, and a deep learning framework to...
This federal Project Grant award of $438,608, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the role of host genetics in shaping the intestinal Lactobacillus population. The project aims to develop a murine model to eliminate environmental factors and study how host genetics directly influence host-commensal interactions, with a specific focus on the...
This Project Grant award, titled "INTEGRATED HOST/MICROBE (IHM) METAGENOMICS OF THE LOWER AIRWAY TO DIAGNOSE PEDIATRIC RESPIRATORY INFECTIONS, IDENTIFY ETIOLOGIC PATHOGENS, AND PREDICT OUTCOMES", is funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The $781,129 award to The Regents of the University of California, San Francisco aims to validate and extend an existing Integrated...
The U.S. National Institute of Child Health and Human Development (NICHD) awarded a $1,376,850 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate interventions for protecting HIV-exposed uninfected infants against severe infections. The project aims to define the relationship between the infant gut microbiome, immune functions, and metabolomic profiles in this population, as well as test dietary interventions to modulate the gut...