This $468,000 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to elucidate the regulation and function of tissue-resident eosinophils at steady state and during allergic disease. The key objectives are to: 1) Target cell cycle machinery to manipulate eosinophil specialization in mucosal tissue, 2) Delineate pre- and post-transcriptional events in eosinophil...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $3,060,713 to New York University School of Medicine to study the effects of obesity and diabetes on antiviral immune responses in the lungs and other organs. The key products and services to be delivered under this 4-year award include: Employing advanced mouse models, bone...
This $760,759 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at the University of Illinois to examine the anti-inflammatory role of the CX3CR1+ conventional dendritic cell type 2 (CDC2) subset in resolving allergic lung inflammation associated with asthma. The key objectives are to characterize the mechanisms by which this CDC2 subset regulates regulatory T cell development and allergic inflammation...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $704,041.00 to the Regents of the University of California at Riverside to investigate sex-dependent innate immune mechanisms in type 2 immunity and obesity. The research aims to 1) study sex differences in macrophage and eosinophil function and their protective role in diet-induced obesity and helminth...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) totaling $831,755 supports research to investigate the role of lung-resident macrophage subsets, particularly nerve- and airway-associated macrophages (NAMs), in regulating type 2 immune responses and tissue homeostasis. The research aims to elucidate the mechanisms by which these macrophage populations mediate protective...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will fund a $590,711 research study to investigate the role of the ICOS costimulatory molecule on group 2 innate lymphoid cells (ILC2s) and their contribution to the pathogenesis of allergic asthma. The 5-year study, beginning June 11, 2025 and ending May 31, 2030, will be conducted by researchers at the University of...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $218,068 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to St. Jude Children's Research Hospital Inc. The grant, titled "IMPACT OF OBESITY ON ANTIVIRAL NK CELL FUNCTION AND IMMUNE CROSSTALK WITH RESPIRATORY EPITHELIAL CELLS DURING INFLUENZA VIRUS INFECTION", will fund research to investigate the impact of obesity on natural killer (NK) cell antiviral responses and the...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $175,000.00 to the La Jolla Institute for Immunology to conduct research on the role of Alternaria fungal sensitization in asthma pathogenesis. The key research objectives are to: Determine the association between Alternaria-specific T cell subsets, including a novel "THIFNR" cell population, and protection...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $115,949 to The Regents of the University of California, San Francisco (UCSF) to support research on the control of adipose immune-stromal niche topography in obesity. The primary objectives are to delineate adipose tissue topography using spatial sequencing, microscopy, and flow cytometry to identify novel signaling or cell...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $746,134 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Vanderbilt University Medical Center. The grant aims to identify the direct immunologic mechanisms by which GLP-1 signaling reduces inflammation to inform the clinical repurposing of GLP-1R agonists for the treatment of both lean and obese patients with asthma. The project will evaluate the anti-inflammatory role of GLP-1...