Project Grant R21AI193813
- This $122,597 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to analyze the function and antibody-mediated inhibition of the malaria vaccine candidate protein PF3D7_1136200. The project aims to characterize this promising but previously uncharacterized blood-stage malaria antigen, with the goal of advancing development of a highly efficacious malaria vaccine. The...
- The University of California, San Francisco (UCSF) was awarded a $675,962 Project Grant by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The purpose of the grant is to characterize the interaction between human and vector behaviors in order to enhance the impact of malaria control interventions in Uganda. The project will integrate rigorous human behavioral and entomological monitoring data to elucidate...
- This federal Project Grant award of $789,442 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Program (CFDA 93.855) supports a multi-omics research study to investigate the role of the myeloid compartment, phagocyte localization, and antibody repertoire in placental malaria immunity. The research team from The Leland Stanford Junior University aims to leverage an extensive biobank of blood and tissue samples from pregnant...
- The University of Washington received a $310,492 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to conduct research on understanding and overcoming Plasmodium-specific immune evasion mechanisms. The research aims to examine how Plasmodium infection influences the pre-vaccine circumsporozoite protein (CSP)-specific memory B cell pool, in order to identify why current malaria vaccines are ineffective in...
- This Project Grant award of $1,553,810 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to evaluate a genomic surveillance approach for monitoring artemisinin resistance in Plasmodium falciparum malaria in Africa. The project aims to identify genetic mutations and altered biological functions associated with artemisinin resistance, which is a critical concern as resistance emerges...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $230,808 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Washington University in St. Louis, Missouri. The funding will support research to identify heme-binding proteins in the malaria parasite Plasmodium falciparum and investigate their role in maintaining heme homeostasis. The project aims to better understand how the parasite detoxifies heme, an essential but redox-active...
- This federal Project Grant award of $791,864 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to identify molecular factors controlling chromatin organization and gene regulation in the malaria parasite Plasmodium falciparum. The research aims to elucidate the importance of long non-coding RNAs (lncRNAs) in parasite development, virulence, and sexual differentiation, with the goal...
- This $147,656 federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand the role of transmembrane proteins in the cell division process of the malaria parasite Plasmodium falciparum. The award, effective January 22, 2025 through October 31, 2027, will enable the integration of biochemical and super-resolution microscopy approaches to decipher...
- This $781,241 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), will support a systems analysis to understand the differential pharmacokinetics and protective efficacy of anti-malarial monoclonal antibodies (mAbs) in field trials. The research aims to leverage prospective clinical data, pharmacokinetic data, and biospecimens from a Phase 2 pediatric trial of the...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $807,330 Project Grant under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to conduct research focused on improving antibody-based protection against Plasmodium falciparum (P. falciparum) and Plasmodium vivax (P. vivax) malaria. The project aims to identify new antibody variants with at least...
This $451,000 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support the development of a comprehensive, high-resolution array to analyze antibody responses to variant Plasmodium falciparum antigens in populations naturally exposed to malaria. The research team at the University of California, San Francisco will leverage advanced bioinformatic and laboratory methods to create a novel phage immunoprecipitation sequencing (PhIP-seq) assay capable of evaluating antibody responses to the full breadth of P. falciparum antigen diversity. This high-resolution array will be applied to longitudinal samples from malaria-endemic regions of Uganda to better understand the development of antibody immunity over time, laying the groundwork for future studies on associations between antibody responses and disease outcomes. The award has a performance period from August 15, 2025 to July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $451.0k | 8/15/25 |