Project Grant R21AI193885
- This Project Grant award of $153,000.00, provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310), focuses on investigating potential radiomitigating strategies for gastrointestinal acute radiation syndrome (GI-ARS). The research project has two novel approaches: 1) Evaluating the mitigating effects of dietary methionine restriction on GI-ARS following radiation exposure, and 2) Exploring a second approach outlined in Aim 2 (details not...
- The U.S. Department of Health and Human Services, National Institutes of Health (NIH) awarded a $155,857 Project Grant under the Trans-NIH Research Support (CFDA 93.310) program to Signablok, Inc. in Massachusetts. The funding supports the development of a novel medical countermeasure to mitigate potentially lethal acute radiation syndrome (ARS). The project aims to create a well-tolerable and effective first-in-class therapeutic that can be administered at least 24 hours post-radiation exposure...
- This $431,750 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to examine the mitigating effects of the small molecule UTS-1401 on both hematopoietic acute radiation syndrome (H-ARS) and gastrointestinal acute radiation syndrome (GI-ARS) following whole body irradiation in Swiss mice. The researchers plan to administer UTS-1401 at various timepoints relative to radiation...
- This Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) provides $159,000.00 to the University of Pittsburgh to research inhibition of the tyrosine kinase FGR as a potential medical countermeasure to mitigate hematopoietic acute radiation syndrome (H-ARS). The research aims to establish FGR as a master regulator of bone marrow inflammation following total body irradiation, and demonstrate that inhibiting FGR can improve bone marrow...
- The U.S. Department of Health and Human Services, National Institutes of Health (NIH) awarded a $164,000 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to Albany Medical College. The grant supports research into "Specialized Pro-Resolving Lipid Mediators for Systemic Radiation Countermeasures". The research aims to develop new therapies to address radiation-induced damage, including hematopoietic effects and chronic inflammation, which can result from...
- This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $155,000 to the University of Kansas Medical Center Research Institute, Inc. (KUMCRI) to investigate the mitochondrial serine/threonine phosphatase PGAM5 as a potential target for mitigating gastrointestinal acute radiation syndrome (GI-ARS). The research aims to examine the role of PGAM5 in radiation-induced oxidative stress and modulation of Wnt/β-catenin...
- This $167,500 Project Grant awarded by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) aims to develop the pentapeptide MSP68 as a novel and effective medical countermeasure to treat the gastrointestinal acute radiation syndrome (GI-ARS). The grant recipient, The Feinstein Institutes For Medical Research, will conduct research to demonstrate that MSP68 can mitigate GI-ARS by promoting the recovery of gut stem cells and reducing intestinal damage...
- This Project Grant award of $158,500 from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) supports the development of a novel non-pharmacological strategy to mitigate radiation-induced cardiotoxicity. Specifically, the research team at the Trustees of Indiana University Indianapolis will investigate the use of a small subcutaneous incision, termed "protective wounding," to enhance hematopoietic recovery and preserve cardiac function in mice...
- This Project Grant award from the Department of Health and Human Services' National Institutes of Health (CFDA 93.310 - Trans-NIH Research Support) provides $149,008 to evaluate the use of PEG-BPEI as a potential mitigator against gastrointestinal acute radiation syndrome (GI-ARS). The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. will develop a murine model of partial body irradiation to study the effects of radiation on the GI tract while minimizing systemic...
- The U.S. Department of Health and Human Services National Institutes of Health (NIH) awarded a $156,000 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to The Medical College of Wisconsin, Inc. The overall objective of this 2-year project, from August 1, 2025 to July 31, 2027, is to develop a panel of biomarkers that can discriminate between exposure of upper- and lower-body organs to radiation and predict health outcomes. The research aims to identify organ-specific...
This Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) totaling $157,000.00 is supporting research to develop a new class of radiation mitigating agents as medical countermeasures for hematopoietic acute radiation syndrome (H-ARS). The principal investigators from the collaborative research partnership between Henry Ford Health and Michigan State University Health Sciences will examine the mitigating effects of the small molecule UTS-1401 on hematopoietic stem cell death and survival when administered up to 72 hours after whole body irradiation. The research will evaluate the radiation mitigation efficacy of three different routes of drug delivery - intravenous, oral, and subcutaneous - to determine the optimal approach. The project period runs from August 18, 2025 to July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $157.0k | 8/18/25 |