The University of Iowa was awarded a $1,354,009 Project Grant from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310). The grant, which runs from September 1, 2024 to August 31, 2027, aims to develop clinically deliverable RNA strategies for radiation protection. Specifically, the project will leverage the protective qualities of extremophile proteins and new delivery methods to reduce the impact of radiation-induced injuries...
This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $157,500.00 to the University of California, Los Angeles (UCLA) to develop and test new radiation mitigator compounds based on the estrogen receptor beta (ER-beta) agonist DPN. The goal is to create orally bioavailable DPN analogues that can more effectively treat bone marrow, gastrointestinal, respiratory, and cardiovascular injuries caused by total-body...
This federal Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $170,800.00 to the New York Blood Center, Inc. to develop a novel radiation countermeasure that addresses sex-dependent radiation response. The research aims to understand the mechanisms underlying sex-specific effects in radiation response regulation and produce a countermeasure that mitigates radiation injuries in a sex-dependent manner. Key...
This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) aims to develop the pentapeptide MSP68 as a novel and effective medical countermeasure to treat gastrointestinal acute radiation syndrome (GI-ARS) in individuals exposed to high doses of ionizing radiation. The $167,500 award to The Feinstein Institutes for Medical Research, a non-profit medical research organization, will fund research to determine the mechanism of...
This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $158,716 to Duke University to conduct research on epigenetic mechanisms involved in the regeneration of intestinal stem cells after severe radiation exposure. The goal is to identify key epigenetic regulators that could help mitigate the effects of gastrointestinal acute radiation syndrome (GI-ARS), which can result in high mortality following radiological...
The National Institutes of Health (NIH) awarded a $239,363 Project Grant under the Research Infrastructure Programs (CFDA 93.351) to The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. The grant aims to determine the radioprotective efficacy of dietary administration of highly radiation-resistant non-pathogenic fungi in the Drosophila model system. The research will evaluate if consumption of these fungal strains can increase resistance to acute radiation damage across...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $149,948 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Leland Stanford Junior University to investigate the role of p53 signaling in endothelial-to-mesenchymal transition and its impact on radiation-induced coronary heart disease. The 2-year project aims to utilize human-induced pluripotent stem cells and transgenic mouse models to elucidate the functional and molecular alterations in the...
This Project Grant award of $760,982.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research at the University of Texas MD Anderson Cancer Center to investigate the role of the enzyme GFPT2 in radiation-induced cardiovascular disease. The key objectives are to elucidate how radiation-induced telomeric DNA damage and subsequent signaling pathways lead to GFPT2 acetylation and stabilization, thereby promoting glutamate metabolism and...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research Federal Grant Program (CFDA 93.837), provides $812,403.00 to The Trustees of the University of Pennsylvania to investigate the mechanisms by which cardiac stereotactic body radiation therapy (CSBRT) impacts ventricular tachycardia (VT) in a large animal model of chronic myocardial infarction. The research aims to better understand the structural and electrophysiologic...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under CFDA 93.837 - Cardiovascular Diseases Research provides $2,290,407.00 to the University of Utah to advance the use of radiation as a non-invasive means of cardiac arrhythmia ablation. The key objectives are to: (1) determine the dose response and structural/functional effects of radiation on cardiac tissue; (2) create radiation targeting strategies using personalized computational models of ventricular...