Project Grant R21AI193636
- The National Institutes of Health (NIH) awarded a $156,000 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to Georgetown University on August 11, 2025. The project, titled "Development of a Multiomic Biodosimetry Panel for Use During Sepsis and Antibiotic Treatment", aims to develop a novel panel of metabolomic and gene expression biomarkers to rapidly screen and provide accurate dose reconstruction for individuals exposed to ionizing radiation. This panel will...
- This Cooperative Agreement award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) provides $616,202 to Brigham & Women's Hospital Inc., a subsidiary of Partners Healthcare System Inc., to identify and develop non-invasive biomarkers of radiation exposure in human skin. The project aims to utilize a model of irradiating human skin grafts carried by immunodeficient mice to identify and validate keratinocyte biomarkers that can discriminate between...
- The U.S. Department of Health and Human Services, National Institutes of Health (NIH) awarded a $164,000 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to Albany Medical College. The grant supports research into "Specialized Pro-Resolving Lipid Mediators for Systemic Radiation Countermeasures". The research aims to develop new therapies to address radiation-induced damage, including hematopoietic effects and chronic inflammation, which can result from...
- The National Institutes of Health (NIH) awarded a $570,849 Cooperative Agreement under the Trans-NIH Research Support program (CFDA 93.310) to Georgetown University to develop predictive biomarker panels to assess the risk of delayed lung and kidney injuries resulting from acute radiation exposure. The goal is to expand existing "LungWatch" and "KidneyWatch" biomarker panels for use in diverse civilian populations and incorporate them into prototype devices. Georgetown...
- The National Institutes of Health (NIH) awarded a $350,000 Cooperative Agreement under the Trans-NIH Research Support program (CFDA 93.310) to The Medical College of Wisconsin, Inc. to deliver a field-ready, physically-based biodosimetry device capable of accurately estimating radiation doses in the range of 0-10 Gy within 0.5 Gy and estimating the homogeneity of irradiation exposure using in vivo measurements of human nails. The project aims to enhance biodosimetry capabilities by improving...
- The U.S. Department of Health and Human Services' National Institutes of Health (NIH) awarded a $170,800 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to New York Blood Center, Inc. The goal of the research project is to understand the mechanism underlying sex-specific effects in the regulation of radiation response and to develop a novel radiation countermeasure that targets such differences. The project aims to determine the cellular and molecular mechanisms of LXN...
- The U.S. Department of Health and Human Services, National Institutes of Health (NIH) awarded a $155,857 Project Grant under the Trans-NIH Research Support (CFDA 93.310) program to Signablok, Inc. in Massachusetts. The funding supports the development of a novel medical countermeasure to mitigate potentially lethal acute radiation syndrome (ARS). The project aims to create a well-tolerable and effective first-in-class therapeutic that can be administered at least 24 hours post-radiation exposure...
- This $153,169 federal Project Grant award from the National Institutes of Health (CFDA 93.310 Trans-NIH Research Support program) to The Ohio State University aims to develop a rapid, non-invasive method for assessing radiation exposure using Raman spectroscopy and artificial intelligence. The project will collect and analyze hair samples from mice exposed to controlled radiation doses to develop models for detecting exposure greater than 2 Grays and differentiating higher doses above 5 Grays....
- This Project Grant award from the Department of Health and Human Services National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) aims to develop a non-invasive, painless biodosimeter using Fourier transform infrared attenuated total reflection (FTIR-ATR) imaging and statistical machine learning. The $197,930 award will fund research to expand upon preliminary data showing FTIR-ATR imaging can distinguish irradiated from control mice at doses as low as...
- This Project Grant award, totaling $156,000.00, was provided by the Office of the Director of the U.S. Department of Health and Human Services' National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310). The project aims to develop a novel, dual-specimen biomarker strategy to improve early detection of gastrointestinal acute radiation syndrome (GI-ARS) using angiotensin-converting enzyme 2 (ACE2) as an early tissue-specific biomarker. The study, conducted by...
The U.S. Department of Health and Human Services National Institutes of Health (NIH) awarded a $156,000 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to The Medical College of Wisconsin, Inc. The overall objective of this 2-year project, from August 1, 2025 to July 31, 2027, is to develop a panel of biomarkers that can discriminate between exposure of upper- and lower-body organs to radiation and predict health outcomes. The research aims to identify organ-specific changes in microRNAs in blood samples following radiation exposure to establish an integrated biomarker signature for radiation biodosimetry. This innovative approach seeks to overcome the current limitations in biomarkers for identifying patterns of partial-body irradiation versus total-body exposure, which is crucial for predicting clinical outcomes after radiation emergencies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $156.0k | 7/29/25 |