This $677,600 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to gain a mechanistic understanding of erythroid progenitor (EP) self-renewal, both in vitro and in vivo. The primary goals are to: Test the hypothesis that the BMI1/RING1B chromatin modulators regulate human self-renewing erythroblast (SRE) self-renewal through epigenetic control of transcription and cholesterol homeostasis. Test the hypothesis that...
This Project Grant award, valued at $735,078, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The funding supports a 5-year research project to investigate the molecular mechanisms of innate immune memory in humans, with a focus on understanding the epigenetic determinants that enable long-lasting "trained immunity" in myeloid and lymphoid progenitor cells. The...
This federal Project Grant award for $378,123 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to identify and test mechanisms that establish transcriptional regulatory potency in early embryos. The primary activities include using genomic methods like PRO-seq, DREG, and OMNI-ATAC to characterize transcriptionally active regulatory elements, DNA accessibility, and...
This Project Grant award of $427,625 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research conducted by the University of Maryland, Baltimore to study the immune-suppressive function of hematopoietic stem and progenitor cells (HSPCs) mediated through the CD27-CD70 pathway. The research aims to determine how HSPC-expressed CD27 can directly inhibit overactive T cells, providing a novel mechanism for HSPCs to...
This Project Grant award of $318,428, provided by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research), supports research at Swarthmore College to elucidate the mechanisms and consequences of nucleic acid sensing in human erythroid progenitors. The research aims to investigate both DNA-sensing and RNA-sensing pathways utilized by erythroid progenitors to contribute to antiviral host defense, as well as characterize the downstream...
This $225,306 Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports a collaborative research project between researchers at the University of Southern California (USC) and a German partner to investigate the long-term impact of early-life growth signals on adult hematopoietic (blood) stem cell function and selection. The key products and services to be delivered under this 3-year award include: 1) using stem cell transplantation and...
This is a Project Grant awarded by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310). The grant, totaling $1,630,964.00, was awarded to the University of Southern California (USC) on September 15, 2024 with a completion date of July 31, 2029. The project aims to study the dynamic spatial configuration of hematopoietic stem and progenitor cells (HSPCs) during blood and immune cell regeneration in the bone marrow. The...
This federal Project Grant award for $657,368.00, issued by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to investigate the mechanisms controlling microRNA (miRNA) processing and degradation pathways during hematopoietic development. The primary awardee, The Washington University, will utilize human pluripotent stem cell lines with mutations in miRNA deadenylases and exosome components to identify novel...
The National Institute of Child Health and Human Development (NICHD) awarded The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania, a $162,500 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) on September 22, 2023. The grant supports the development of tools to visualize the construction and assembly of the Posterior Signaling Center (PSC), a cell niche that controls the progenitors of insect...
This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $159,512 to generate a comprehensive single-cell transcriptomic and epigenomic map of human bone marrow cells and experimentally establish the mesenchymal hierarchy in human bone. The primary goals are to unravel the complex cellular signaling networks in bone marrow and provide insights into how cell fates are regulated, with the long-term aim of developing novel...