The University of Rochester received a $677,600 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The grant supports collaborative research to gain a mechanistic understanding of erythroid progenitor self-renewal, both in vitro and in vivo. The goal is to expand erythroid progenitors, which is essential for maintaining steady-state erythropoiesis and responding to acute anemic or hypoxic stress. The research will investigate how the BMI1/RING1B chromatin modulators regulate erythroid progenitor self-renewal through epigenetic control of transcription and cholesterol homeostasis. This work aims to bring a renewable source of human erythroblasts closer to the clinic to meet specialized transfusion needs. The award has an initial performance period of 4 years, from August 1, 2024 to July 31, 2028.
Generated 3/4/25, 6:08 AM