Project Grant R21AI193443
- The National Institute of Allergy and Infectious Diseases awarded the University of California, Los Angeles $744,483 on June 16, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how epigenetic heterogeneity and temporal signaling dynamics in B-cell selection shape antibody repertoires and vaccine responses. The funded research examines B-cell fate decisions during antibody-mediated immunity through two primary aims. Aim 1 investigates how dynamic...
- Federal Project Grant Award Summary The University of California, San Diego received a $438,500 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective July 8, 2025, through June 30, 2027. The award supports basic immunological research focused on understanding the mechanisms that regulate immunoglobulin gene rearrangement, specifically investigating how enhancers and epigenetic...
- The National Institute of Allergy and Infectious Diseases awarded Yale University $751,919 on June 17, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on transcriptional control of activation-induced deaminase function. This Project Grant (R01AI192485) funds investigation into the molecular mechanisms coordinating activation-induced deaminase (AID)-mediated deamination with RNA polymerase 2 transcription. Understanding these mechanisms is...
- The National Institute of Allergy and Infectious Diseases, a component of the Department of Health and Human Services National Institutes of Health, awarded $120,312 to the University of California, Berkeley on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds research into adenosine deaminases acting on RNA (ADARs), enzymes that edit RNA to regulate gene expression and immune responses. The research aims to identify viral and host...
- The National Institute of Allergy and Infectious Diseases awarded The Regents of the University of California, San Francisco $182,196 on June 4, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop antibody-driven bioconjugation methods that chemically modify primary immune cells and disease-associated proteins to redirect cytotoxicity toward diseased cells as an alternative to genetic engineering approaches. The award funds synthesis and characterization...
- The National Institute of Allergy and Infectious Diseases awarded The Regents of the University of California, San Francisco $666,065 on June 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the molecular basis for immunogenic B cell responses to virus-like antigen display. The research leverages a modular platform of liposomes decorated with model antigens to independently control epitope affinity and density. The work aims to identify proximal...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $438,500 Project Grant to the University of California, San Diego under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 8, 2025, with a completion date of June 30, 2027. This award funds investigator-initiated biomedical research examining the sequence-specific determinants and impacts of NS2 (nonstructural protein 2) interactions with the Influenza A Virus...
- The National Institute of Allergy and Infectious Diseases awarded Scripps Research Institute $552,000 on July 16, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate plasma cell longevity and survival mechanisms beyond antibody production. The research uses engineered mouse models, specifically a double fate-mapper system designed to track long-lived plasma cells over time and understand the molecular, cellular, and clonal properties they acquire as they...
- The National Institute of Allergy and Infectious Diseases awarded the University of California Irvine $301,936 on January 16, 2026, for Project Grant F32AI194808 under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds research investigating the role of cystatin F expression on microglia in constraining demyelination following viral infection of the central nervous system. The research uses a murine neurotropic JHM strain of mouse hepatitis virus (JHMV) model...
- The National Institute of Allergy and Infectious Diseases awarded Scripps Research Institute $772,010 on July 23, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct mechanistic studies of combination adjuvants in B cell memory establishment. The research examines how three adjuvants formulated together in a vaccine—an NKT cell agonist, a TLR7 agonist, and a QB virus-like particle (VLP)—cooperate to produce high-affinity protective anti-bacterial glycan...
The National Institute of Allergy and Infectious Diseases awarded $234,151 to the University of California, Davis on August 14, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the mechanism of mRNA polyadenylation in immunoglobulin heavy chain genes during the differentiation of activated B cells into plasma cells. The research leverages single-cell-level RNA measurement coupled with RNA hybridization-based flow cytometry and CRISPR-based genome editing to interrogate heavy chain RNA processing, which is essential for antibody secretion. The project aims to elucidate the context and sequence of post-transcriptional processing events that enable the transition from B cells to antibody-secreting plasma cells—a process coordinated by the IRF4 and BLIMP-1 transcription factors. The molecular discoveries are intended to inform the design of small-molecule agonists and antagonists to enhance humoral immunity. Performance occurs in Davis, California. The period of performance extends from the award date through July 31, 2028. This is a Project Grant, a standard assistance mechanism supporting investigator-initiated research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $234.2k | 8/14/26 |