Project Grant R01AI192485
- Federal Grant Award Summary Yale University received a $3.13 million Project Grant from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded July 25, 2025, with a completion date of June 30, 2029. The grant funds investigator-initiated biomedical research focused on elucidating the mechanisms of lymphoid-specific beta-catenin protein degradation in B-lymphoid cells. The research will characterize how B-cells...
- Federal Project Grant Award Summary Yale University received a $405,585 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded on July 18, 2025, with completion targeted for June 30, 2027. The grant supports the development of a multiplexed CRISPR activation and interference (CRISPRa/i) system designed to elucidate gene regulatory networks underlying T cell development in primary...
- Federal Project Grant Award Summary Yale University received a $251,938 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded June 12, 2026, with completion targeted for May 31, 2028. The award funds research to discover and develop cell-intrinsic immunologic adjuvants designed to enhance next-generation self-amplifying RNA (saRNA) vaccines. The primary deliverable is investigation of...
- Federal Project Grant Award Summary Yale University received a $105,402 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective September 27, 2026, with a completion date of April 15, 2029. The award supports investigator-initiated biomedical research focused on understanding the mechanisms of resilience to cytokinopathy flares in autoinflammatory diseases. The research addresses...
- Federal Grant Award Summary Yale University received a $735,631 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded April 1, 2026, with completion targeted for March 31, 2031. The research focuses on investigating the origin and functional properties of CX3CR1+ neutrophils, a novel neutrophil population with distinct biological characteristics compared to canonical neutrophils....
- Federal Grant Award Summary Award Details: Yale University received a $251,875 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award was obligated on May 4, 2026, with a project completion date of April 30, 2028, and performance at Yale's New Haven, Connecticut location. Research Objectives and Deliverables: This award funds research aimed at elucidating the structural mechanisms...
- Federal Grant Award Summary Yale University received a $373,090 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded August 25, 2025, with a completion date of July 31, 2026. The award supports development of Modular Degraders of Extracellular Proteins (MODES), a novel therapeutic approach designed to remove pathogenic extracellular proteins from circulation. The research program...
- Federal Grant Award Summary Yale University received a $662,465 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) on February 6, 2026, with an ultimate completion date of January 31, 2031. This research initiative, titled "Durable and Broad Airway Immunity Through Next-Generation Intranasal Boosters," focuses on developing and understanding next-generation mucosal...
- Federal Grant Award Summary Yale University received a $819,674 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective May 15, 2026, with a completion date of April 30, 2031. The award supports the development of mechanistically informed deep learning computational models and experimental methodologies to identify autoreactive B cells in myasthenia gravis (MG), an...
- Federal Grant Award Summary Yale University received a $251,938 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded June 9, 2026, with completion targeted for May 31, 2028. The grant supports investigator-initiated biomedical research focused on characterizing heterogeneity in autoimmune myasthenia gravis (MG) by identifying and analyzing disease variants driven by distinct immune...
Summary Yale University received a $751,919 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective June 17, 2026, with a completion date of May 30, 2031. This research initiative investigates the transcriptional control mechanisms of Activation Induced Deaminase (AID) function, specifically examining how AID-mediated DNA deamination coordinates with RNA Polymerase 2 (POL2) transcription to enable somatic hypermutation (SHM) and class switch recombination (CSR)—critical processes for generating high-affinity antibodies and vaccine efficacy. The research will deliver scientific knowledge regarding factors such as POL2 pause factor NELF, super elongation complex components, and protein phosphatase complexes that regulate this collaborative process. The project's primary deliverables encompass mechanistic research findings addressing how POL2 regulatory factors enable AID-POL2 collaboration in SHM and CSR, utilizing novel methodological advances including rapid assay for SHM (RASH) cells combined with degron technology. The research addresses fundamental immunological mechanisms while contributing to understanding how aberrant AID-mediated deamination drives genetic instability and B-cell malignancies, thereby advancing knowledge within the broader infectious disease and immunologic research domain supported by NIAID's program objectives.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $751.9k | 6/19/26 |