Project Grant K99AI201800
- The National Institute of Allergy and Infectious Diseases awarded William Marsh Rice University $2,538,587 on July 8, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the molecular mechanisms by which ADAR1 (adenosine deaminase acting on RNA) regulates RNA-induced immune responses and modulates immunostimulatory pathways. The research dissects how ADAR1 recognizes and edits diverse immunostimulatory RNAs to modulate their structure and...
- The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, awarded $571,412 to the University of Maryland, College Park on June 11, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds research into the regulation of bacterial physiology and infections through linear diribonucleotides and RNA degradation. The project will characterize how diribonucleases and triribonucleases bind their respective...
- The National Institute of Allergy and Infectious Diseases awarded $234,151 to the University of California, Davis on August 14, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the mechanism of mRNA polyadenylation in immunoglobulin heavy chain genes during the differentiation of activated B cells into plasma cells. The research leverages single-cell-level RNA measurement coupled with RNA hybridization-based flow cytometry and CRISPR-based genome...
- The National Institute of Allergy and Infectious Diseases awarded the University of California, San Diego $480,000 on September 16, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the molecular basis for arboviral fitness in vector and reservoir hosts. The research examines how arboviruses replicate across evolutionarily distant hosts—insects and vertebrates—despite showing high specificity in their transmission cycles. Using alphaviruses as a...
- The National Institute of Allergy and Infectious Diseases awarded Yale University $242,958 on July 7, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate RNA structure probing approaches for understanding pro-inflammatory RNA helicases. The research applies chemical probing techniques—specifically co-transcriptional structure tracking (COSTSEQ) combined with DMS-MAPSEQ—to identify RNA substrates that DEAD-/DEAH-box helicases remodel and to map functional...
- The National Institute of Allergy and Infectious Diseases awarded the Regents of the University of California at Riverside $213,048 on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how SARS-CoV-2's nucleocapsid (N) protein manipulates host-cell translation machinery to establish viral replication during early infection. The research identifies the molecular mechanisms by which N protein physically and functionally interacts with human...
- The National Institute of Allergy and Infectious Diseases awarded San Diego Biomedical Research Institute $992,920 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) for research on nanoscale imaging of cell surface HIV envelope immune complexes to optimize natural killer cell antibody-dependent cellular cytotoxicity (ADCC) therapeutics. The project integrates nanoscale imaging, machine learning, and in silico protein modeling to characterize the...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $438,500 Project Grant to the University of California, San Diego under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 8, 2025, with a completion date of June 30, 2027. This award funds investigator-initiated biomedical research examining the sequence-specific determinants and impacts of NS2 (nonstructural protein 2) interactions with the Influenza A Virus...
- The National Institute of Allergy and Infectious Diseases awarded Beckman Research Institute of the City of Hope $489,500 on February 5, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to identify and characterize novel molecular pathways regulating inflammatory responses, with particular focus on non-canonical mir-146a biogenesis and its role in immune homeostasis. The research will characterize post-transcriptional mechanisms controlling mir-146a production,...
- The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services National Institutes of Health, awarded $577,181 to The University of Texas MD Anderson Cancer Center on July 9, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to dissect a pyroptotic mechanism driven by gasdermin A (GSDMA) activation. The research examines how GSDMA is activated in sterile inflammatory conditions and cancer, focusing on the role of the...
The National Institute of Allergy and Infectious Diseases, a component of the Department of Health and Human Services National Institutes of Health, awarded $120,312 to the University of California, Berkeley on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds research into adenosine deaminases acting on RNA (ADARs), enzymes that edit RNA to regulate gene expression and immune responses. The research aims to identify viral and host factors that dysregulate RNA editing during infection, determine the mechanisms by which these factors modulate ADAR activity, and examine how dysregulated RNA editing affects immune activation and disease outcomes. The project will combine bioinformatics, high-throughput screening, and functional assays to map editing outcomes and reveal how eukaryotic viruses manipulate RNA editing as a strategy to evade host defenses. Findings will clarify fundamental principles of host-virus conflict and inform potential therapeutic applications, including controlling excessive RNA editing in cancer and enhancing tumor immunotherapy, or improving therapeutic RNA editing to treat diseases caused by ADAR insufficiency such as Aicardi-Goutieres syndrome. Work is performed in Berkeley, California. The period of performance runs from September 1, 2026, through August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $120.3k | 8/27/26 |