This federal Project Grant award of $219,456 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to understand how sterile inflammation at the maternal-fetal interface impacts the developing fetal immune system in a non-human primate model. The research aims to test the hypotheses that 1) injecting the clotting agent Tisseel into the maternal-fetal interface leads to placental inflammation, and 2) this...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 - Allergy and Infectious Diseases Research, provides $205,999 over 5 years to support a research program focused on understanding maternal-fetal immune interactions and the potential impact of environmental exposures on susceptibility to infection during pregnancy. The primary goal is to develop a cohort of young investigators with the skills to conduct high-quality...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $793,102 to Wake Forest University Health Sciences (WFUHS) to investigate the interplay of maternal antibody and newborn vaccine responses to influenza virus. The goal is to effectively vaccinate young infants when maternal antibody levels are high, so that as maternal antibody wanes, a protective...
The University of Southern California received a $621,698 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) to conduct research on mother-to-child transmission of hepatitis B virus (HBV). The goal is to understand how HBV and its antigens in the mother affect the anti-HBV immunity of her children, which can lead to chronic HBV infection. The research will identify maternal HBV factors that promote HBV...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $214,742 to Texas A&M University to research mechanisms of Toxoplasma gondii vertical transmission and placental barrier crossing. The researchers aim to identify and characterize key T. gondii proteins, such as TgMIF, that enable the parasite to infect the fetus by crossing the placental barrier. They will use...
This Project Grant award of $789,442 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research on placental malaria and immunity in pregnant women. The primary objectives are to: 1) Determine how malaria and gravidity impact the circulating and placental blood myeloid compartment in pregnancy using single cell proteomic and transcriptomic approaches; 2) Assess how Plasmodium falciparum...
This $112,956 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research at Texas A&M University System Health Science Center to study how biological sex impacts innate immune and metabolic responses that influence infection susceptibility. The award aims to leverage the Drosophila melanogaster genetic model to assess the impact of post-mating reproductive changes in females, but not males,...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports a research study to identify newborns with in-utero SARS-CoV-2 infection and assess their immune response and clinical outcomes. The study plans to screen 3,600 newborns using cord blood testing and other methods to detect in-utero infection. It will also conduct longitudinal follow-up on a subset of 100 infected...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $2,999,774 to the Regents of the University of Minnesota to conduct research focused on understanding how maternal microbial exposure fundamentally shapes the CD8 T cell population at the maternal-fetal interface. The key objectives are to investigate the regulation of CD8 T cell tolerance and host immune defense...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1,336,490 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Sloan-Kettering Institute for Cancer Research in New York, NY. The 5-year grant, awarded on August 6, 2024, supports research to understand B cell and antibody responses to placental versus foreign antigens, with the goal of illuminating how dysregulated responses contribute to pregnancy complications and informing...