Project Grant R01AI189601
Award Date
4/17/25
Completion Date
3/31/30
Dollars Obligated
$793K
Federal Agency
National Institute of Allergy and Infectious Diseases
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Winston-Salem, NC 27157, USA
Similar Awards
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), funds research to understand how antigen duration and vaccine construct modulate the infant immune response to influenza vaccines. The $456,390 award, granted on March 21, 2025, will support studies exploring a prolonged antigen delivery approach that resulted in significantly increased influenza-specific antibody...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $633,074 to the Sloan-Kettering Institute for Cancer Research in New York to study maternal B cell and antibody responses during pregnancy. The research aims to define the mechanisms by which placental antigens are suppressed from triggering harmful B cell activation and antibody production, while preserving immunity...
This $596,636 Project Grant award was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports research to determine how optimal protective humoral immunity is induced and maintained during influenza infection. The key objectives are to test the hypothesis that early influenza infection triggers distinct B cell activation pathways mediated by TLR3/TRIF and MYD88 signaling, which...
This $205,999 project grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to investigate maternal-fetal immune responses against infections, including SARS-CoV-2 and malaria, during pregnancy. The award will enable the development of a cohort of young investigators to conduct high-quality translational research in the field of perinatal infectious diseases. Key objectives...
This $184,896 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 "Allergy and Infectious Diseases Research" supports a five-year research and career development program. The grant aims to evaluate the potential of mRNA-lipid nanoparticle (mRNA-LNP) platforms and lipid nanoparticle (LNP) adjuvants to overcome maternal antibody interference, a major barrier to early life immunization against diseases like influenza and measles....
This $586,250 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will fund research to investigate how age-associated B cell (ABC) subsets can protect the elderly from influenza. The primary aim is to determine the potential of different ABC subsets to respond to influenza infection, generate antibody-secreting cells, establish B cell memory, and provide long-term protection. This includes comparing the...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) is focused on studying the impact of influenza vaccination during pregnancy on maternal influenza disease severity, infant anthropometric outcomes, and the cost-effectiveness of different vaccination timing strategies in rural Nepal. The USD 320,788 award, effective from June 21, 2024 to January 15, 2026, will leverage data...
This Project Grant award of $404,479.00, awarded on August 15, 2024 by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to gain mechanistic insights into the kinetics of Fc receptor-mediated placental antibody transfer. The goal is to optimize maternal vaccine strategies and improve protection for infants against serious infections early in life. Key objectives include: (I) identifying...
This $682,008 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to advance the development of monoclonal antibodies (mAbs) for the treatment of infectious diseases caused by paramyxoviruses, with a specific focus on parainfluenza virus (PIV). The key objectives are to: 1) define the human B cell repertoire to PIV surface proteins, 2) determine the optimal therapeutic...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will fund research to define the mechanistic features of interleukin-27 (IL-27) signaling at the maternal-fetal interface and its protective capacity during congenital infection. The $556,002 award aims to elucidate the immune regulatory and antiviral functions of IL-27 in regulating inflammation and viral infection at...