This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $2,999,774 to the Regents of the University of Minnesota to conduct research focused on understanding how maternal microbial exposure fundamentally shapes the CD8 T cell population at the maternal-fetal interface. The key objectives are to investigate the regulation of CD8 T cell tolerance and host immune defense against pathogens at this critical interface, utilizing innovative natural microbial exposure models as well as human tissue samples. The research aims to gain mechanistic insights into the tissue-localized CD8 T cell types, receptors, and specificity, along with identifying beneficial and pathogenic host factors that maintain immune tolerance while providing protection against microbial infections. The project period runs from July 2025 through June 2029.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $3.0m | 7/17/25 |