Project Grant R21AI190640
- Federal Project Grant Award Summary Weill Medical College of Cornell University received a $2.94 million Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded July 23, 2025, with completion targeted for June 30, 2029. This research initiative will advance scientific understanding of resistance and tolerance mechanisms to nitroimidazole drugs (pretomanid and delamanid) in Mycobacterium...
- Federal Grant Award Summary Weill Medical College of Cornell University received a $254,250 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded August 7, 2025, with a completion date of July 31, 2027. The project focuses on developing and testing proteolysis-targeting chimeras (PROTACs) as a novel therapeutic approach to degrade mycobacterial protein kinase G (PKNG) within host...
- Federal Project Grant Summary Cornell University received a $746,602 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 1, 2025, through July 31, 2030. The award supports research into novel therapeutics for tuberculosis (TB) treatment through the chemical stimulation of cyclic adenosine monophosphate (cAMP) production in Mycobacterium tuberculosis (MTB). The research...
- GRANT AWARD SUMMARY The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant of $3,178,476 to the Sloan-Kettering Institute for Cancer Research on January 28, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports a four-year research project (through December 31, 2029) investigating chalkophore-mediated respiratory oxidase flexibility as a virulence determinant in Mycobacterium tuberculosis. The research will utilize...
- Federal Grant Award Summary Albany Medical College received a $451,000 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded February 6, 2026, with a completion date of January 31, 2028. The grant funds investigator-initiated biomedical research focused on elucidating the role of the Wnt/β-catenin signaling pathway in alveolar epithelial repair during tuberculosis (TB) infection and...
- Federal Project Grant Award Summary Tufts University School of Medicine received a $536,148 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 7, 2025, through July 31, 2030. The award supports a prospective cohort study integrating point-of-care urine isoniazid testing into routine tuberculosis (TB) treatment protocols within India's National TB Program. The...
- Federal Project Grant Award Summary Tufts University School of Medicine received a $156,080 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded January 29, 2026, with completion targeted for August 15, 2028. The grant funds research investigating the spatio-temporal modulation of innate immune cells in relation to Mycobacterium tuberculosis (MTB) stress response and replication...
- Federal Project Grant Award Summary Albert Einstein College of Medicine received an $850,711 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded August 1, 2025, with a completion date of July 31, 2030. The research initiative focuses on developing non-sputum-based point-of-care tests (POCTs) for tuberculosis (TB) detection in resource-limited settings, addressing a World Health...
- Federal Project Grant Award Summary Award Details: Weill Medical College of Cornell University received a $806,208 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded September 4, 2025, with completion targeted for August 31, 2030. Research Services Provided: The award funds a spatial omics research initiative investigating hepatitis B virus (HBV) control in people with HBV/HIV...
- Federal Project Grant Award Summary National Jewish Health received a $429,546 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded August 8, 2025, with completion targeted for July 31, 2027. The grant funds research to develop improved preclinical measures for evaluating tuberculosis (TB) treatment regimen efficacy by utilizing transcriptomic analysis rather than traditional...
Grant Award Summary Weill Medical College of Cornell University received a $442,146 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded February 6, 2026, with completion scheduled for January 31, 2028. The research project investigates salicylate-based drugs—specifically the principal metabolite of aspirin—as adjuvants to potentiate bedaquiline's anti-tuberculosis (TB) activity. This research addresses rising rates of low-level bedaquiline resistance that threaten recent advances in treating drug-resistant TB, with preliminary data demonstrating that salicylates enhance bedaquiline's anti-TB activity at human-achievable concentrations. The funded research deliverables include quantifying and validating the synergistic anti-TB effects of salicylates and bedaquiline combinations, identifying optimal concentrations for maximum efficacy, and exploring whether other salicylate-based nonsteroidal anti-inflammatory drugs demonstrate stronger proton-shuttling capabilities. These research outputs are intended to support potential strategies for shortening bedaquiline-based treatment regimens to less than six months and combating existing low-level resistance to current second-line TB therapies. The work will be conducted at Weill Medical College's New York, NY location.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $442.1k | 2/6/26 |