Project Grant R01AI185330
- This $1,640,492 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to the Albert Einstein College of Medicine is supporting research on the ESX5 secretome of Mycobacterium tuberculosis, the causative agent of tuberculosis (TB). The researchers have generated a genetic deletion mutant of the ESX5 transport system, which they have found to be a promising live attenuated vaccine candidate for preventing TB in...
- The Project Grant award of $743,651 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will fund research to develop plasma cell-free RNA (cfRNA) signatures as a novel biomarker for tuberculosis (TB) diagnosis and treatment monitoring. The Regents of the University of California, San Francisco will lead this 5-year translational research project, which aims to validate the accuracy of cfRNA signatures in detecting active TB...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $238,500 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of California, San Diego (UCSD) to develop a novel electrochemical lateral flow assay (ELFA) for point-of-need tuberculosis (TB) detection. The objective is to create a highly sensitive and specific ELFA test that can accurately diagnose active TB, even in challenging populations like those with HIV...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $3,089,360 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Rutgers, The State University of New Jersey. The 5-year grant, which began on September 10, 2025, will establish a consortium of experienced investigators and a global network of clinical research sites to support the evaluation of early-stage tuberculosis (TB) diagnostic tests. The program aims to accelerate the...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $253,497 Project Grant under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) to The Trustees of Columbia University in the City of New York to evaluate innovative methods to improve tuberculosis (TB) detection, prevention, and treatment among migrant communities in New York City. The proposed SPOT-TB intervention will utilize mobile diagnostic teams integrating portable digital chest...
- This $854,000 project grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to assess and characterize post-tuberculosis (TB) lung disease in TB patients with and without HIV coinfection. The grant recipient, The Johns Hopkins University, will utilize novel positron emission tomography (PET) imaging techniques to longitudinally profile lesional characteristics in animal...
- The National Institute of Allergy and Infectious Diseases (NIAID), part of the U.S. Department of Health and Human Services, awarded a $536,148 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Trustees of Tufts College, doing business as Tufts University School of Medicine, to conduct research on integrating point-of-care urine isoniazid testing into routine tuberculosis (TB) care in India. The central goal is to enable early and accurate identification...
- This $4,760,584 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to address the critical unmet need for better tuberculosis (TB) diagnostics in high-burden countries. The primary objectives are to: Solicit, review, and prioritize the most relevant novel TB diagnostics across different phases of development and use cases for evaluation during the award period. Conduct...
- This $193,375 Project Grant, awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to identify bacterial determinants that may contribute to variable treatment responses for tuberculosis (TB). The project, conducted by researchers at the Harvard T.H. Chan School of Public Health, aims to investigate the effects of clinically prevalent variants in the ESX1 secretion system on TB...
- This federal Project Grant award of $429,546.00, provided by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research), supports research to evaluate regimen efficacy for tuberculosis (TB) treatment using transcriptomic patterns of Mycobacterium tuberculosis injury and adaptation. The primary objective is to determine if regimens that more rapidly and profoundly induce a common bacterial "injury pattern" can shorten the time...
The federal Project Grant award of $850,711 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research at the Albert Einstein College of Medicine to develop novel biomarkers for the detection of tuberculosis (TB). The goal is to identify highly sensitive and specific non-sputum-based point-of-care tests (POCTs) for active TB diagnosis, particularly in resource-limited settings and people living with HIV. The research focuses on utilizing a panel of six monoclonal antibodies to enhance the detection of the TB lipoglycan lipoarabinomannan (LAM) in urine and exhaled breath concentrate, with the aim of achieving the WHO target diagnostic sensitivity and specificity for sputum-smear-positive and -negative TB regardless of HIV status. The award has an initial term of 5 years, from August 1, 2025 to July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $850.7k | 7/30/25 |