Project Grant R01AI182659
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $298,829 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Tarn Biosciences, Inc. to develop novel nitroreductase-activated inhibitor compounds as treatments for tuberculosis (TB) and nontuberculous mycobacterial (NTM) infections. The funding, awarded on August 21, 2025, supports the discovery and preclinical development of a lead candidate compound, HC2210, which has shown...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $429,546 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to National Jewish Health in Colorado. The grant will fund research to evaluate the efficacy of tuberculosis (TB) treatment regimens by analyzing the transcriptomic patterns of Mycobacterium tuberculosis injury and adaptation during drug treatment. The research aims to develop more reliable preclinical measures of TB treatment...
- This $193,375 Project Grant, awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to identify bacterial determinants that may contribute to variable treatment responses for tuberculosis (TB). The project, conducted by researchers at the Harvard T.H. Chan School of Public Health, aims to investigate the effects of clinically prevalent variants in the ESX1 secretion system on TB...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $4,760,584 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) federal grant program to the Regents of the University of California, San Francisco (UCSF) for the "RAPID RESEARCH FOR DIAGNOSTICS DEVELOPMENT IN TB NETWORK: EPISODE 2 (R2D2 TB NETWORK II)" project. The goal of this project is to address the critical unmet need for better tuberculosis (TB) diagnostics in high-burden...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $832,076 Project Grant under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) to the University of Massachusetts Medical School (UMMS) to conduct research on protective CD8 T cell responses to tuberculosis (TB). The research aims to characterize how vaccine-elicited CD8 T cells respond to Mycobacterium tuberculosis (MTB) challenge, identify protective antigens recognized by CD8 T cells,...
- The National Institute of Allergy and Infectious Diseases (NIAID), through its Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $238,500 project grant to the University of California, San Diego (UC San Diego) to develop a novel electrochemical lateral flow assay (ELFA) for the point-of-need diagnosis of tuberculosis (TB). The objective is to create a highly sensitive and specific blood or urine test that can accurately distinguish active TB disease from...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $690,538 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Washington for the project "EXPANDING ACCESS AND IMPACT OF TUBERCULOSIS PREVENTIVE THERAPY: COMMUNITY-FRIENDLY DELIVERY AND MONITORING OF TPT TO IMPROVE UPTAKE AND REDUCE TB TRANSMISSION." The project aims to explore new, person-friendly models of tuberculosis preventive therapy (TPT) delivery to...
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded a $750,000 Project Grant to The University of Southern Mississippi to research the role of extracellular polyphosphate in Mycobacterium tuberculosis antibiotic tolerance. The 4-year grant, which begins on Sep 20, 2025 and runs through Aug 31, 2029, aims to investigate the metabolic pathways in M. tuberculosis that regulate extracellular...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $774,881 Project Grant under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) to The Johns Hopkins University on February 24, 2025. The grant will support research to investigate the use of pro-apoptotic drugs, such as navitoclax, as host-directed therapies for treating pulmonary tuberculosis (TB). The research aims to evaluate how these drugs impact lung immune response, tissue...
- The federal Project Grant award of $3,089,360 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports the development and evaluation of innovative tuberculosis (TB) diagnostic platforms and assays. The 5-year project, awarded to Rutgers, The State University of New Jersey, aims to accelerate promising TB diagnostics through a fast-paced pipeline that includes technology scouting, development...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $536,148 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Tufts University School of Medicine to conduct research on integrating point-of-care urine isoniazid testing into routine tuberculosis (TB) care in India. The research aims to facilitate early and accurate identification of TB patients who are at risk of poor outcomes, including death and disease recurrence, due to medication nonadherence. The project involves a prospective cohort study with translational research on the clinical, behavioral, and implementation aspects of integrating urine testing into India's national TB program. The grant award is effective from August 2025 through July 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $84.9k | 8/20/25 | ||
| Not listed | $451.2k | 8/7/25 |