Project Grant R01AI196228
- Federal Project Grant Award Summary Tufts University School of Medicine received a $156,080 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded January 29, 2026, with completion targeted for August 15, 2028. The award funds research to elucidate spatio-temporal innate immune cell modulation of Mycobacterium tuberculosis (MTB) stress response and replication heterogeneity. The...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $2.86 million through the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Regents of the University of Minnesota for a four-year project (August 1, 2025 – July 31, 2029). The project investigates the mechanisms by which CD4 T cells activate myeloid cells to control Mycobacterium tuberculosis (MTB) infection and enhance protection against tuberculosis. The research employs...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant of $227,096 to the Regents of the University of California, University of California, Berkeley under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period of July 1, 2025 through June 30, 2027. This research project focuses on utilizing random barcode transposon site sequencing (RB-TNSEQ) as a genetic screening tool to identify nutrient...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Regents of the University of California, San Francisco a $492,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective August 1, 2025, through July 31, 2030. This five-year research initiative focuses on the biochemical and structural characterization of the elongasome and divisome protein complexes in Mycobacterium tuberculosis (MTB), the...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Massachusetts Medical School $832,076 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on August 8, 2025, for a project period extending through July 31, 2030. This Project Grant supports basic and translational research aimed at characterizing protective CD8 T cell responses to Mycobacterium tuberculosis (MTB) infection. The research program combines...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Health Research, Inc.'s Wadsworth Center Division a $1,378,102 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective July 18, 2025, with completion targeted for June 30, 2030. This five-year research initiative focuses on developing and evaluating mycobacteriophage lysin (LYSB) as a therapeutic agent against Mycobacterium abscessus (MAB) infections,...
- Federal Project Grant Award Summary Cornell University received a $746,602 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 1, 2025, through July 31, 2030. The award supports research focused on developing novel tuberculosis (TB) therapeutics that stimulate cyclic adenosine monophosphate (cAMP) production in Mycobacterium tuberculosis (MTB). The research will...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant of $188,760 to the University of Washington, effective September 1, 2025, through August 31, 2030, under the Allergy and Infectious Diseases Research program (CFDA 93.855). This five-year research initiative will be conducted at the University of Washington in Seattle and focuses on advancing scientific understanding of tuberculosis immunity through investigation of...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $209,408 Project Grant to the University of Pittsburgh under the Allergy and Infectious Diseases Research program (CFDA 93.855) on September 19, 2025, with completion scheduled for August 31, 2030. This research initiative delivers scientific investigation into early T cell responses during tuberculosis (TB) infection using a non-human primate model of Mycobacterium tuberculosis (MTB)...
- Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $151,040 to The Washington University under the Allergy and Infectious Diseases Research program (CFDA 93.855) on December 23, 2025, for a project grant extending through June 30, 2028. This award supports fundamental research investigating the mechanisms of sigma-factor-dependent transcriptional control in Mycobacterium tuberculosis (MTB), the bacterium responsible for approximately 1.6 million...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $3.18 million Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Sloan-Kettering Institute for Cancer Research, effective January 28, 2026, with a completion date of December 31, 2029. This research project investigates chalkophore-mediated respiratory oxidase flexibility and its role in Mycobacterium tuberculosis virulence. The funded work will discover and characterize components of the chalkophore biosynthetic and handling systems through genetic, chemical biological, and proteomic approaches, while defining the metal-responsive transcriptional switches that control respiratory oxidase flexibility and identifying host pathways that target M. tuberculosis respiration during infection. The research builds upon established findings demonstrating that diisonitrile chalkophores—copper-chelating natural products produced by M. tuberculosis—are essential for bacterial virulence in mouse infection models. Deliverables under this award will include scientific characterization of the chalkophore biosynthetic system, identification of regulatory mechanisms controlling oxidase function, and elucidation of host immune mechanisms targeting M. tuberculosis respiration independent of adaptive immunity. These research outputs are intended to advance understanding of tuberculosis pathogenesis and identify potential therapeutic targets.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.2m | 1/28/26 |