The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $185,513 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the University of Arkansas for Medical Sciences (UAMS) to develop O'PROTACS-based degraders that specifically target the expression of LANA, a Kaposi's sarcoma-associated herpesvirus (KSHV) encoded oncoprotein. The goal is to interfere with the survival of KSHV-positive tumor cells in vitro and in vivo, providing new interventional...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $221,105 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Arkansas for Medical Sciences (UAMS). The grant, awarded on May 1, 2025, with a completion date of April 30, 2027, will support research to investigate how APOBEC3 enzymes impact the evolution of poxviruses, such as monkeypox virus, and their ability to evade host immune responses. The study aims to...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $658,273 to the University of Massachusetts Medical School to conduct research on how Herpes Simplex Virus 1 (HSV-1) interacts with and regulates the NLRP1 inflammasome pathway in human skin cells. The key goals are to: 1) Identify the mechanisms by which HSV-1 activates and inhibits the NLRP1 inflammasome, 2)...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $471,159 to the University of California, Irvine to conduct research on the role of interferon lambda in alpha herpesvirus neuroinvasion. The research aims to elucidate the mechanisms of local axonal responses to interferon lambda and their effects on viral invasion of the nervous system, as well as how these...
This federal Project Grant award, with ID R01DE035025, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The $583,289 grant will fund a 5-year research project at the University of Arkansas for Medical Sciences (UAMS) to study the epigenetic regulation of Kaposi's sarcoma-associated herpesvirus (KSHV) latency. The research aims to advance the understanding of how KSHV, which causes several...
The federal Project Grant award for "Deciphering the Mechanisms of Nucleolar Stress Response During MCPyV Infection" was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The $104,984 award, with a performance period from September 2024 to July 2026, supports research at Pennsylvania State University to investigate how the Merkel Cell Polyomavirus (MCPyV) induces the nucleolar stress...
This federal Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the stability of gene therapy vectors based on adeno-associated viruses (AAVs) when challenged by natural viral infections in human hepatocytes. The $284,331 award to the University of Massachusetts Medical School aims to develop novel methods to characterize the structure and...
This Project Grant award of $892,050.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will fund research at the University of Missouri at Kansas City (UMKC) to investigate how plant viruses modulate host chromatin dynamics and gene expression. The key objectives are to: Determine how the PEMV2 virus P26 protein induces chromatin compaction and alters host gene expression, potentially repressing...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $651,832.00 to The Children's Hospital of Philadelphia Research Institute. The funding supports research to understand how the Herpes Simplex Virus (HSV) manipulates the host cell's DNA damage response and proteome to promote viral gene expression and replication. The research team will utilize global proteomic...
This Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the dynamics and evolution of HIV Gag and GagPol processing. The $752,745 award aims to use molecular dynamics simulations, single-molecule FRET imaging, and cryo-electron tomography to probe the structure and dynamics of Gag and GagPol that enable ordered processing by the viral...