This federal Project Grant award of $651,832.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research supports research to define how changes to the proteome by ATM-activated signaling and ICP0-mediated ubiquitination alter recruitment of proteins onto viral genomes to promote Herpes Simplex Virus (HSV) gene expression and replication. The project aims to elucidate the intersection of phosphorylation and ubiquitination and their combined impact on the DNA damage response during HSV infection, as well as determine how ubiquitination and ATM-signaling promote HSV infection by examining proteins associated with viral genomes. The award was granted to The Children's Hospital of Philadelphia Research Institute, a leading pediatric medical research institution, and will be conducted from November 15, 2024 to October 31, 2029. The research seeks to advance understanding of cellular systems that control viral infection, with potential implications for developing novel antiviral therapies and prevention strategies.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $651.8k | 11/14/24 |