This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), part of the Oral Diseases and Disorders Research program (CFDA 93.121), provides $1,337,014 to study the mechanisms by which the human Kaposi's sarcoma-associated herpesvirus (KSHV) manipulates cellular metabolism to facilitate viral replication and tumorigenesis. The key products and services to be delivered under this award include: 1) determining how KSHV's viral cyclin (vCyclin) hijacks the host...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $185,513 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the University of Arkansas for Medical Sciences (UAMS) to develop O'PROTACS-based degraders that specifically target the expression of LANA, a Kaposi's sarcoma-associated herpesvirus (KSHV) encoded oncoprotein. The goal is to interfere with the survival of KSHV-positive tumor cells in vitro and in vivo, providing new interventional...
This federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $564,698.00 to the University of California, Davis to conduct a study on the Kaposi's sarcoma-associated herpesvirus (KSHV). The research aims to better understand the KSHV gene regulation and identify new drug targets to control KSHV replication and associated neoplasms like Kaposi sarcoma, multicentric Castleman disease, and primary effusion lymphoma. The project will focus on...
This federal Project Grant award, provided by the National Cancer Institute (CFDA 93.396 - Cancer Biology Research), supports research to understand how the Kaposi's sarcoma-associated herpesvirus (KSHV) manipulates cellular metabolic pathways and the N6-methyladenosine (m6A) epitranscriptome to maximize both latent and lytic viral infections. The $1,349,322 award to the University of Pittsburgh aims to: 1) identify KSHV-regulated METTL16-specific m6A marks during latent and lytic infections and...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $601,309 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the University of Florida. The grant, which runs from Jul 1, 2025 to Mar 31, 2030, seeks to understand viral mechanisms that could inform the development of oncolytic therapies for Epstein-Barr virus (EBV)-associated lymphomas in people living with HIV. The research aims to identify core upstream mechanisms that disrupt...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to the University of Arizona in the amount of $118,763 for the period of September 1, 2024 to August 31, 2026. The grant will support Dr. Robert Jackson's research focused on assessing the role of human papillomavirus type 16 (HPV16) in transforming versus productive infections in oral epithelial tissues. The research aims to characterize the viral...
This Project Grant award of $178,000.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to characterize the biogenesis and biological significance of protein phosphoribosylation in the context of herpes simplex virus 1 (HSV-1) infection. The research aims to: 1) identify and characterize the enzyme(s) that catalyze the ADP-ribosylation of the HSV-1 structural protein VP22, and...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, is supporting research to investigate the role of antiretroviral therapy (ART) in susceptibility to oral human papillomavirus (HPV) infection. The $1,913,543 award to Louisiana State University Health Sciences Center New Orleans will fund a 5-year study with three specific aims: 1) comparing the prevalence and incidence of...
This Project Grant award of $2,740,126 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will fund research to understand the factors contributing to increased oropharyngeal cancer (OPC) among people living with HIV (PWH). The University of Alabama at Birmingham will conduct this 5-year research project to investigate how chronic HIV infection and inflammation impact HPV infection, gene expression, and T...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is supporting research at the University of Arkansas for Medical Sciences (UAMS) to investigate the role of lytic viral genes in the development and maintenance of oncogenic gammaherpesvirus cancers. The $420,335 award, spanning June 2025 to May 2027, will enable UAMS researchers to use in vivo models to test the hypothesis...