Project Grant R21AI187932
Award Date
7/1/25
Completion Date
6/30/27
Dollars Obligated
$458K
Federal Agency
National Institute of Allergy and Infectious Diseases
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Farmington, CT 06032, USA
Similar Awards
The University of South Florida was awarded a $509,130 Project Grant by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research to define the role of the BosR regulator in controlling virulence gene expression and the infectious cycle of the Lyme disease pathogen Borrelia burgdorferi. Key objectives include characterizing the BosR regulon, examining the regulation of BosR expression,...
This $382,500 five-year Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research supports research at Washington State University to study the functional and mechanistic aspects of the Lyme disease spirochete's genetic factors encoded on plasmid LP17. The key objectives are to: 1) Establish the importance of genes BBD21 and BBD22 for controlling the copy number of Borrelia burgdorferi plasmids and the...
This Project Grant award of $461,375.00 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research at Yale University to systematically identify interactions between Lyme disease bacteria, Borrelia burgdorferi, and proteins from its tick vector, Ixodes scapularis. The goal is to develop a comprehensive database of these pathogen-vector interactions, which can inform strategies to block transmission or interrupt the...
This Project Grant award of $191,250 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research by Washington State University to study the mechanism of antigenic variation in the Lyme disease spirochete, Borrelia burgdorferi. The research aims to decipher the role of specific genetic factors in the expression and recombination of the VlsE surface protein, which is a key mechanism for immune...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research (CFDA 93.855) program, provides $162,000.00 to The Johns Hopkins University to conduct research on how the spirochete Borrelia burgdorferi, the causative agent of Lyme disease, uses epidermal growth factor (EGF) as an environmental cue to coordinate its gene expression during the infection cycle. The research aims to characterize the binding of EGF...
The Virginia Commonwealth University was awarded a $746,009 Project Grant from the Department of Health and Human Services National Institutes of Health National Institute of Allergy and Infectious Diseases. The grant falls under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research examining the cyclic-di-GMP signaling pathway and its role in the enzootic cycle of Lyme disease from November 18, 2022 through October 31, 2027. Specifically, the grant will fund...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $192,500.00 to the University of South Alabama to conduct research on the mechanisms of Borrelia burgdorferi central nervous system invasion in a mouse model of Lyme disease. The goal is to identify key pathways of bacterial entry into the central nervous system and associated host immune responses, which could...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $2,014,302 to Montana State University to conduct research on the role of phage FBB-1 in the horizontal gene transfer and infection dynamics of the Lyme disease spirochete Borrelia burgdorferi. The research aims to: 1) measure horizontal gene transfer between B. burgdorferi strains in ticks, 2) define the...
This federal Project Grant award in the amount of $3,019,293 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports a prospective 5-year study to investigate the causes and mechanisms of Post-Treatment Lyme Disease Syndrome (PTLDS), a complex condition that lacks consensus on diagnosis and treatment. The study is being conducted by a multidisciplinary team of clinicians,...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $299,933 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to L2 Diagnostics LLC, a for-profit biomedical research company based in Woodbridge, Connecticut. The project aims to develop a novel therapeutic using a secretory leukocyte protease inhibitor (SLPI) to mitigate Lyme arthritis and post-treatment Lyme disease syndrome. The award period runs from July 8, 2024 to June 30, 2026....