This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $299,608 to examine the role of Proteus mirabilis RTX proteins in polymicrobial biofilm formation and the pathogenesis of catheter-associated urinary tract infections (CAUTI). The award aims to: 1) investigate the expression of P. mirabilis RTX proteins during polymicrobial biofilm formation and determine their...
This $1.23 million Project Grant from the National Institutes of Health's National Institute of Allergy and Infectious Diseases will fund research at Loyola University of Chicago from June 2022 to May 2025 under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant aims to further the university's investigation into how certain species of Lactobacillus bacteria found in the female urinary tract can control colonization of uropathogenic Escherichia coli (UPEC) through...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will provide $239,348 to support research at Columbia University investigating the impact of regulatory T cells (Tregs) on host susceptibility to Pseudomonas aeruginosa infection. The goal is to evaluate whether Tregs protect against P. aeruginosa pneumonia by altering the airway metabolome composition and reducing metabolites...
This $153,540 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to identify genetic risk variants associated with urinary tract infections (UTIs). The project aims to perform human genome-wide association studies (GWAS) to discover novel candidate genes, like PSCA, that may contribute to UTI susceptibility. The research...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $185,544 to Vanderbilt University Medical Center (VUMC) to support research on understanding the role of arginine metabolism in antibiotic treatment failure during Staphylococcus aureus infections. The 5-year project, beginning on August 20, 2024 and ending on July 31, 2029, aims to elucidate the mechanisms by which...
This Project Grant award of $453,621.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to understand how changes in the lipopolysaccharide (LPS) composition of the bacterial pathogen Pseudomonas aeruginosa (PA) influence aggregate formation and social behaviors in chronic cystic fibrosis lung infections. The key products and services to be delivered include: (1) determining the frequency of PA...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), CFDA # 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program, provides $632,600.00 to the University of Texas at Dallas (UTD) to conduct a comprehensive analysis of the role of antimicrobial peptides called defensins in immunity against urinary tract infections (UTIs). The primary objectives are to: 1) Examine whether defensins synthesized by bladder...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $817,252 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Vanderbilt University Medical Center (VUMC) to conduct a study entitled "Investigating Multiple PK and PD Relationships for TB-HIV (IMPPROVE TB-HIV)". This 1-year project aims to leverage VUMC's Tuberculosis Sentinel Research Network to perform pharmacokinetic-pharmacodynamic (PK-PD) analyses on first-line...
This $779,915 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research by the Scripps Research Institute to investigate the chromatin remodeling functions of polyphosphate condensates in the bacterial pathogen Pseudomonas aeruginosa. The project aims to define the relationship between polyphosphate and the DNA-binding protein AlgP in regulating gene expression and...
This Project Grant award for $400,000.00 was provided by the National Institute on Aging under the Aging Research federal grant program (CFDA 93.866) to Baylor College of Medicine. The objective is to define the molecular pathways underlying how aging makes the bladder epithelium prone to urinary tract infections (UTIs) and develop new therapeutics to target those pathways. The research aims to determine the role of ribosomal and translational quality control machinery in bladder homeostasis,...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $1,010,671 to Vanderbilt University Medical Center (VUMC) to elucidate how the uropathogen Pseudomonas aeruginosa establishes acute urinary tract infections (UTIs) and whether age influences infection establishment and persistence. The research aims to define how specific mutations in the respiratory complex of uropathogenic Pseudomonas strains contribute to respiration within the bladder epithelial environment, as well as determine the pathogenesis steps followed by Pseudomonas in young versus old bladders, including differences in the immune response. The findings have the potential to change how Pseudomonas infections are mitigated in the elderly population by informing the development of diagnostic tools and identifying modifiable host factors. VUMC has also awarded a $124,439 sub-grant to Columbia University to support this research.