Project Grant R21AI181780

Award Date 11/12/24
Completion Date 10/31/26
Dollars Obligated $239K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
New York, NY 10032, USA
Similar Awards
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will provide $239,348 to The Trustees of Columbia University in the City of New York to investigate a newly identified population of CD1a-restricted T cells that respond to the lipid antigen phosphatidylglycerol (PG). The research aims to determine the conditions under which mitochondrial PG becomes visible to these T...
This Project Grant award, valued at $194,740, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The funding supports research to characterize the development of lung-resident, self-antigen-specific regulatory T cells (Tregs) following acute lung injury, with the goal of understanding how these "experienced" Tregs can promote tolerance and prevent future lung disease. The...
This $783,557 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research to examine the molecular determinants and functions of bacterial polysaccharide cellular localization in Pseudomonas aeruginosa (PA) biofilms. The research aims to determine how the PSL and PEL exopolysaccharides exist in different chemical forms and how their cellular localization is...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) totaling $831,755 supports research to investigate the role of lung-resident macrophage subsets, particularly nerve- and airway-associated macrophages (NAMs), in regulating type 2 immune responses and tissue homeostasis. The research aims to elucidate the mechanisms by which these macrophage populations mediate protective...
This $246,000 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research supports research to investigate the role of lung repair and regeneration pathways in tuberculosis (TB). The award aims to determine the functional role of the bone morphogenetic protein (BMP) signaling pathway in TB control and reactivation, as well as characterize the cellular mechanisms of BMP pathway activation during TB...
This $162,000 Project Grant, awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), will fund research to characterize the role of plasmacytoid dendritic cells (pDCs) in Mycobacterium tuberculosis (MTB) infection. The Washington University, the grant recipient, will leverage their mouse model of MTB infection to quantify pDC lung trafficking, identify the chemokine receptor required for pDC lung...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $907,242.00 to study how changes in bacterial surface properties influence social behaviors of Pseudomonas aeruginosa, a major pathogen in cystic fibrosis lung infections. The research aims to determine how lipopolysaccharide (LPS) composition affects aggregate formation, antibiotic tolerance, and social...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $3,413,412 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Texas Biomedical Research Institute to study mechanisms for controlling Mycobacterium tuberculosis (MTB) infection in the lungs. The project aims to understand the immune responses generated by an attenuated, live-replicating MTB strain that has demonstrated protective efficacy in non-human primate models....
This $868,776 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to characterize the role of a novel post-transcriptional regulator called PhfA in the opportunistic pathogen Pseudomonas aeruginosa. The primary objectives are to: 1) Identify the direct regulatory targets of PhfA in the laboratory strain P. aeruginosa PAO1 and in clinical isolates, under both...
This $779,915 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research by the Scripps Research Institute to investigate the chromatin remodeling functions of polyphosphate condensates in the opportunistic pathogen Pseudomonas aeruginosa. The project aims to define the relationship between polyphosphate and the DNA-binding protein AlgP in regulating gene...

This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $239,348 to investigate the role of regulatory T cells (Tregs) in protecting against Pseudomonas aeruginosa lung infections. The award, granted to The Trustees of Columbia University in the City of New York, Health Sciences Division, will evaluate how Tregs alter the airway metabolome to limit bacterial growth and biofilm formation, as well as assess the contribution of Treg-derived adenosine signaling through CD73 expression. The findings are expected to reveal new pathways for controlling intractable P. aeruginosa lung disease. This award, with a performance period from November 2024 to October 2026, supports fundamental research to advance the understanding of host immune responses and their impact on bacterial pathogenesis.

Generated 7/1/25, 2:52 AM