This $462,500 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to decipher the genetic regulation of bacterial heterogeneity in response to antibiotic stress using single-cell transcriptomics. The 5-year award period runs from January 1, 2025 through November 30, 2029. The primary research objective is to comprehensively characterize bacterial heterogeneity during...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $895,538 to support research aimed at developing shorter and more effective oral regimens for the treatment of Mycobacterium abscessus pulmonary disease. The research aims to discover all-oral sterilizing drug regimens, either using FDA-approved agents or integrating novel preclinical and clinical candidates, in order to...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $240,878 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Medical University of South Carolina. The purpose of this R34 clinical trial planning grant is to develop a detailed protocol and documentation to conduct a future randomized, blinded, placebo-controlled clinical trial evaluating the efficacy and safety of the antibiotic omadacycline, in combination with other...
This three-year Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences totals $1,512,792 to fund research at Louisiana State University examining the gene regulatory networks affected by purine catabolites in bacterial pathogens. The research aims to identify additional transcription factors in Burkholderia thailandensis responsive to urate and xanthine, which accumulate in host tissues during infection due to production of reactive oxygen species....
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $155,227 to investigate a new treatment approach for Mycobacterium abscessus (MAB) chronic lung disease. The key objectives are to generate proof-of-concept data on using a monoclonal antibody (CMTX-101) to disrupt MAB biofilms in the lungs, which can improve the effectiveness of antibiotic treatments that...
The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded a $294,824 Project Grant to the University of Massachusetts Medical School (UMass Medical) to investigate the use of glutamine starvation as a means to enhance antibiotic efficacy against Mycobacterium tuberculosis (MTB), a major public health threat responsible for nearly 2 million deaths annually. The project aims to understand the mechanistic...
This $254,478 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to identify mechanisms of resistance to pathogen-specific antibacterial antisense compounds known as peptide-phosphorodiamidate morpholino oligomers (PPMOs). The goal is to determine resistance mechanisms for lead PPMO compounds in the bacterial pathogens Klebsiella pneumoniae, Acinetobacter...
This federal Project Grant award, valued at $637,275.00 and awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to uncover the mechanisms by which Gram-negative bacterial pathogens develop rapid tolerance to chemical stressors, such as antibiotics. The research aims to elucidate how these bacteria can inhibit the functioning of existing porin proteins in their outer membranes...
This $630,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to investigate the connection between arginine phosphorylation and the CIpC1P1P2 protease in Mycobacteria. The project aims to use phosphoproteomics to identify stress conditions that elevate phosphoarginine (parg), assess the requirement of parg on Mycobacterial stress tolerance, and identify the relevant kinases...
This $2,308,174 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) is funding research to develop new antimicrobial combinations and strategies to combat the threat of drug-resistant Acinetobacter baumannii and Klebsiella pneumoniae. The key products and services being delivered include: Generating novel mechanistic insights into antibiotic resistance mechanisms and bacterial...