The University of Florida (UF) Division of Sponsored Research has been awarded a $2,308,174 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop new antibiotic combinations for combating gram-negative pathogens like Acinetobacter baumannii and Klebsiella pneumoniae that are resistant to current treatments.
The grant supports a multi-pronged research effort that includes:
- Using mechanistic assays and mathematical modeling to gain insights into how different antibiotic binding profiles and resistance mechanisms impact bacterial killing and resistance suppression.
- Evaluating optimized antibiotic combination regimens against the target pathogens in a hollow fiber infection model.
- Testing the most promising regimens in mouse models of pneumonia to assess performance with and without granulocytes.
Key sub-awards support specialized chemical synthesis, flow cytometry, and mathematical modeling contributions from researchers at the University of Central Florida, Children's Hospital Los Angeles, and St. Jude Children's Research Hospital. The project aims to provide critical insights that can inform the development of new combination therapies to combat antimicrobial resistance.
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