This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $346,677 to the University of Delaware to investigate the connection between arginine phosphorylation and the mycobacterial ClpC1P1P2 protease. The research aims to identify stress conditions that elevate phosphoarginine (pArg) modifications in mycobacteria, assess the requirement of pArg for mycobacterial stress tolerance, and determine how pArg binding influences the activity and assembly state of the ClpC1P1P2 protease. Additionally, the project will examine how pArg-dependent changes in the ClpC2 protein affect its role in dormancy and persistence. The outcomes are expected to expand the understanding of pArg-linked proteolytic pathways in mycobacteria, which could aid in the development of new therapeutic leads targeting the ClpC1 protease.
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