This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research to develop an injectable 3D-clustered human fibroblastic reticular cell (FRC) formulation for expanding regulatory T cells (Tregs) to induce allograft transplant tolerance. The total funding amount is $231,131 and the award period runs from June 11, 2025 to May 31, 2027. The research, conducted by Duquesne University, aims to optimize the FRC formulation to promote Treg generation in vitro and characterize the cell depots' ability to support Tregs in vivo using humanized mouse models. The goal is to advance FRCs as a potential cell therapy for inducing immune tolerance in allograft transplantations, providing an alternative to current immunosuppressive drug regimens.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $231.1k | 6/11/25 |