This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) will support a proof-of-concept study to develop a cell-based therapy for generating donor-specific immune tolerance in kidney transplant patients. The $210,867 award to Drexel University, valid from February 1, 2025 to January 31, 2027, will fund the engineering of tolerogenic dendritic cells (toldcs) containing microparticles loaded with a...
This $1,529,805 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to enhance regulatory myeloid cell function and improve kidney transplant survival in nonhuman primates. The award aims to develop innovative strategies for prolonging kidney allograft survival and enabling immunosuppression withdrawal, including:
Testing an agonistic LILRB3 monoclonal antibody combined with baseline...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Brigham & Women's Hospital Inc. The $195,126 grant, awarded on Jun 14, 2024, supports research to enhance the response of regulatory CD8 T cells and promote allograft tolerance for organ transplants.
The key objectives of the research project are to: 1) develop a tolerogenic superagonist that specifically stimulates human CD8...
The National Institutes of Health National Institute of Allergy and Infectious Diseases awarded a $1,074,434.37 Project Grant to the Massachusetts General Hospital under the Allergy and Infectious Diseases Research program (CFDA 93.855) on March 17, 2021 with a completion date of July 12, 2021.
The grant funding supports research to develop protocols to induce tolerance in non-human primate heart allograft recipients without chronic immunosuppression. The awardee will test approaches to...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) provides $440,452 to Rutgers, The State University of New Jersey, to characterize the molecular targets of early allograft injury in liver transplantation (LT). The goal is to (1) define the protective pathways activated by hypothermic oxygenated machine perfusion (HMP-O2) compared to static cold storage (SCS), and (2) identify biomarkers for organ...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $612,975 to the University of Pittsburgh to conduct research aimed at achieving long-term acceptance of organ transplants without the need for ongoing immunosuppression. The key goals of the 5-year project are to: 1) develop a model for blocking the CD47 protein in addition to inhibiting T cell costimulation...
This $264,596 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will support research to assess the use of serum microRNA (miRNA) profiling to safely taper immunosuppression in liver transplant recipients. The project aims to establish a prospective randomized study protocol to evaluate whether miRNA profiles can detect early signs of immune response and allograft injury, allowing for personalized...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports a research project focused on the molecular control of tolerogenic dendritic cell function. The $246,623 award to New York University School of Medicine aims to pinpoint the dendritic cell subset responsible for maintaining T cell tolerance, characterize the molecular basis including cytokine production and signaling, and delineate the...
This $4,506,493 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to investigate age-related changes in transplant immunity and develop new treatments for older transplant recipients.
The award funds three interrelated research projects at Brigham & Women's Hospital, a major academic medical center in Boston. Project 1 will examine how cellular senescence in lymph node stromal cells...
This federal Project Grant award of $748,049 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research, supports a multi-center validation and biologic assessment of a novel pre-transplant biomarker panel to predict liver transplant recipient mortality.
The key objectives are to: 1) Perform multicenter validation and refinement of the Liver Immune Frailty Index (LIFI), a pre-transplant...