The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $417,984 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Scripps Research Institute in La Jolla, California. The grant, awarded on March 7, 2025, will support research to identify actionable targets for the selective induction of regulatory T cell (Treg) differentiation. The research aims to address a key knowledge gap in understanding the biology and application of naive CD4...
This federal Project Grant award, totaling $649,053, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports research at The Washington University in Missouri to investigate the role of Ly49 family receptors on CD8 T cells and their function in regulating immune responses. Specifically, the project aims to understand how Ly49 and the transcription factor Helios contribute to the...
This Project Grant award, valued at $194,740, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The funding supports research to characterize the development of lung-resident, self-antigen-specific regulatory T cells (Tregs) following acute lung injury, with the goal of understanding how these "experienced" Tregs can promote tolerance and prevent future lung disease. The...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $658,657 to support research aimed at understanding the biophysical mechanisms by which protein condensates functionally couple with ordered lipid domains in T-cells. The primary awardee, the University of Virginia, will conduct an integrated investigation spanning biophysical characterization, live-cell...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $202,488 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Cedars-Sinai Medical Center. This 2-year grant, running from February 2025 to January 2027, will fund research to characterize the distinct roles of Tox protein isoforms in T cell and innate lymphoid cell (ILC) development. The project aims to investigate the function of these Tox isoforms, which arise through translational...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $597,542 in funding to Emory University to conduct research on the metabolic and epigenetic regulation of skin regulatory T cells (Tregs). The key objectives of this research project are to: 1) dissect the specific metabolic program governing the homeostasis of skin Tregs in their microenvironment, and 2)...
This Project Grant award of $737,502 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to investigate the role of the WDFY4 protein in regulating antigen presentation by dendritic cells and its impact on regulatory T cell (Treg) development and function. The key objectives are to: 1) Determine how WDFY4 affects the T cell receptor repertoire, particularly in Tregs, and assess the...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will provide $639,084 to support research aimed at elucidating the heterogeneity of naive CD8 T cells and how this contributes to immune response and T cell homeostasis in mice. The research will also define a human naive CD8 T cell atlas by examining antigen-specific CD8 T cells in young, aged, and newborn populations....
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $612,975.00 to fund research aimed at achieving long-term acceptance of organ transplants without the need for chronic immunosuppression. The research seeks to develop a translational model that combines T-cell costimulation blockade with inhibition of monocyte allorecognition via CD47 to induce long-term graft...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $246,623 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to New York University School of Medicine to conduct research on the molecular control of tolerogenic dendritic cell function. The overarching goal is to delineate the molecular mechanisms underlying the tolerogenic function of dendritic cells and their role in promoting immune tolerance. The 2-year project, spanning November 2024 to...