Project Grant R21AI185488
- Federal Grant Award Summary Applied Biomedical Science Institute received a $976,318 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective April 6, 2026, with a completion date of March 31, 2031. The research focuses on elucidating the molecular mechanisms underlying bovine antibody structural variegation, specifically the generation of ultralong complementarity-determining...
- Federal Grant Award Summary The University of Massachusetts Medical School received a $460,625 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective February 9, 2026, with a completion date of January 31, 2028. The research project, "Eliciting TH1/TH17 Dual Responses for Vaccine-Induced Immunity to Tuberculosis," investigates mechanisms by which the Bacillus...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $204,375 to the Trustees of Boston University (Boston University Medical Campus) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop next-generation human immune system (HIS) mice models for vaccine testing against high-containment viruses. The project, which commenced June 1, 2026 and concludes May 31, 2028, addresses a critical gap in vaccine development...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $815,378 Project Grant to the Trustees of Boston University (Boston University Medical Campus) effective May 1, 2026, through April 30, 2031, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The research initiative focuses on identifying and characterizing high-affinity germline-encoded antibodies that can neutralize viral pathogens causing significant...
- Federal Project Grant Award Summary Award Details: Abvacc, Inc. received a $638,953 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award was issued on August 22, 2025, with a completion date of July 31, 2030, and performance will be conducted in Rockville, Maryland. Products and Services: The grant funds development of an immunotherapeutic antibody cocktail for treating...
- Federal Grant Award Summary Albany Medical College received a $164,000 Project Grant award from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective June 6, 2025, with completion targeted for May 31, 2027. The project, "Development of Conformer-Specific Anti-I-A Class II Monoclonal Antibodies," focuses on identifying and characterizing novel monoclonal antibodies (MAbs) that selectively recognize...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Massachusetts General Hospital a Project Grant of $439,088 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective July 8, 2025, through July 7, 2027. The award supports research led by Dr. Daniel Lingwood, Associate Professor of Medicine at the Ragon Institute of Mass General, MIT and Harvard, to mechanistically define how sex differences in hormones and...
- Grant Award Summary Boston University Medical Campus received a $245,250 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded on February 9, 2026, with a completion date of January 31, 2028. This research initiative investigates the mechanisms of alternative macrophage activation in pulmonary tuberculosis (TB), focusing on understanding the phenotypes and genesis of arginase 1...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Texas Biomedical Research Institute $905,998 under the Allergy and Infectious Diseases Research program (CFDA 93.855) to evaluate the safety, immunogenicity, and efficacy of a novel attenuated Mycobacterium tuberculosis (MTB) vaccine candidate in the context of HIV co-infection. Commencing June 17, 2025, and extending through May 31, 2030, this project will leverage the institute's...
- Federal Project Grant Award Summary Albert Einstein College of Medicine received a $780,787 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective January 27, 2026, with completion targeted for December 31, 2030. The award supports fundamental research aimed at understanding how T cell receptor (TCR) recognition of peptide ligands shapes memory CD8+ T cell programming, with...
ANTIBODY MEDIATED IMMUNITY AGAINST BRUCELLA - ABSTRACT: NO VACCINES ARE CURRENTLY LICENSED TO PREVENT HUMAN BRUCELLOSIS AND EXISTING VACCINES FOR LIVESTOCK ARE NOT ENTIRELY EFFICACIOUS. IN HUMANS AND OTHER ANIMALS, BRUCELLA CAN CAUSE A LIFELONG INFECTION. HOWEVER, MECHANISMS UNDERLYING THE ABILITY OF BRUCELLA TO SUBVERT ADAPTIVE IMMUNITY REMAIN UNCLEAR. IN THIS PROPOSAL WE SHOW THAT VACCINE ELICITED ANTIBODIES ALTER HOST METABOLISM TO PROTECT THE HOST AGAINST BRUCELLA TO SOME DEGREE. THEREFORE, IN SPECIFIC AIM #1 OF THIS PROPOSAL WE WILL DETERMINE HOW VACCINE-ELICITED IGM AND CLASS SWITCHED ANTIBODIES ALTER TISSUE METABOLISM TO RESTRICT BRUCELLA INFECTION. WE ALSO FOUND THAT BRUCELLA ENCODES VIRULENCE FACTORS THAT MEDIATE EVASION OF HUMORAL IMMUNITY. THEREFORE, IN SPECIFIC AIM #2 OF THIS PROPOSAL WE WILL IDENTIFY MECHANISMS BY WHICH BRUCELLA SUBVERTS ANTIBODY MEDIATED IMMUNITY. COLLECTIVELY, OUR RESULTS WILL ENHANCE OUR UNDERSTANDING OF HOW CURRENT VACCINES PROTECT THE HOST, AND HOW BRUCELLA IS ABLE TO SUBVERT ADAPTIVE IMMUNITY, AND THUS COULD IMPROVE THE RATIONAL DESIGN OF HIGHLY EFFECTIVE VACCINES FOR BRUCELLA.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 5/5/26 | ||
| Not listed | $233.1k | 7/15/25 | ||
| Not listed | $0 | 4/28/25 | ||
| Not listed | $0 | 4/28/25 | ||
| Not listed | $193.9k | 7/25/24 |
GrantNumber | Description | Subgrantee | Prime Award | Dollars Obligated | Updated At |
|---|---|---|---|---|---|
C000857851S | Montana State University | Project Grant R21AI185488 | $94.3k | 9/29/25 |