Project Grant R21AI196552
- Federal Grant Award Summary The University of Massachusetts Medical School (UMMS) received a $832,076 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 8, 2025 through July 31, 2030. This award supports investigator-initiated biomedical research focused on understanding protective CD8 T cell responses to tuberculosis (TB) caused by Mycobacterium tuberculosis...
- Federal Grant Award Summary The University of Massachusetts Medical School received a $104,262 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded on September 30, 2025, with a completion date of May 31, 2028. This research project, titled "Linking Mycobacterium tuberculosis Infection Outcomes with Transcriptional Networks in Genetically Diverse Mouse Macrophages,"...
- Federal Grant Award Summary Tufts University School of Medicine received a $490,704 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded February 10, 2026, with completion expected January 31, 2028. The grant supports the development of spatial multi-omics methodologies to predict granuloma trajectory and bacterial restriction during tuberculosis (TB) vaccination. Specifically, the...
- Federal Grant Award Summary Boston University Medical Campus received a $245,250 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded February 9, 2026, with a completion date of January 31, 2028. The grant supports research investigating the mechanisms of alternative macrophage activation in pulmonary tuberculosis (TB), specifically examining the phenotypes and genesis of arginase...
- Federal Grant Award Summary The University of Massachusetts Medical School received a $472,210 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective June 23, 2025, through May 31, 2027. The grant supports biomedical research investigating T-cell mediated neutrophil recruitment during lung infection, with specific focus on understanding how prior respiratory pathogen exposure...
- Federal Project Grant Award Summary Tufts University School of Medicine received a $156,080 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded January 29, 2026, with completion targeted for August 15, 2028. The grant funds research investigating the spatio-temporal modulation of innate immune cells in relation to Mycobacterium tuberculosis (MTB) stress response and replication...
- Summary of Federal Project Grant Award The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Massachusetts a $224,943 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) on September 18, 2025, with a completion date of August 31, 2027. This research project, titled "Cell Wall Carbohydrate Recycling in Mycobacterium tuberculosis," will be conducted at the University of Massachusetts' facility in Hadley, MA. The...
- Federal Project Grant Award Summary Boston Medical Center Corporation received a $711,993 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) on June 11, 2025, with completion targeted for May 31, 2026. This award funds investigator-initiated biomedical research examining the effects of Mycobacterium tuberculosis (MTB) disease on HIV-1 (Human Immunodeficiency Virus) pathogenesis,...
- Federal Project Grant Award Summary The University of Massachusetts Medical School received a $1.75M project grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded on February 24, 2025, with a completion date of January 31, 2030. This research project investigates the immunobiology of a novel human damage-associated molecular pattern (DAMP) receptor designated CLEC17A, its murine homolog...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Massachusetts Medical School $840,687 on August 15, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct a five-year research project (completion date July 31, 2030). The project investigates the molecular mechanisms by which Bruton's tyrosine kinase (BTK) inhibition—drugs approved to treat B cell cancers—increases susceptibility...
The University of Massachusetts Medical School (UMMS) received a $460,625 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded February 9, 2026, with a completion date of January 31, 2028. This research project investigates immune mechanisms underlying vaccine-induced protection against tuberculosis (TB) by examining how BCG (Bacillus Calmette-Guerin) vaccination modifies host immunity to generate protective hybrid-TH1/TH17 immune responses. The work utilizes the Collaborative Cross (CC) mouse model to identify immune correlates of vaccine-induced protection, with particular focus on the CC037 strain, which demonstrates superior protection against Mycobacterium tuberculosis infection following BCG vaccination. The primary deliverable is basic science research examining how dendritic cell (DC) modifications induced by BCG vaccination lead to the generation of hybrid-TH1/TH17 immune populations. This research aims to identify immune signatures associated with vaccine-induced protection that are not apparent in traditional animal models, potentially advancing the understanding of BCG vaccine efficacy and informing development of improved TB vaccines. The work addresses a critical public health gap, as TB remains a leading cause of death from infectious disease globally despite over a century of BCG vaccination across more than 200 countries.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $460.6k | 2/9/26 |