Project Grant R21AI182953

Award Date 8/15/24
Completion Date 7/31/26
Dollars Obligated $235K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Baton Rouge, LA 70803, USA
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This $234,586 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to develop a glycoconjugate vaccine for preventing infection with the bacteria Acinetobacter baumannii. The key products and services to be delivered include:

  1. Chemical synthesis of glycan components from A. baumannii, including a pentasaccharide O-glycan and fragments of a lipooligosaccharide (LOS). These glycans will be used to produce well-characterized glycoconjugates for immunological study.

  2. Covalent conjugation of the A. baumannii glycans to carrier proteins like CRM197 to create glycoconjugate vaccine candidates.

  3. Immunological evaluation of the glycoconjugates in mice, including assessing antibody titers, binding to A. baumannii, and protective effects against infection.

A sub-award to LSU Health Sciences Center New Orleans will support the in vivo immunization studies and challenge experiments with A. baumannii to determine the protective capacity of the most promising glycoconjugate vaccine candidates.

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