Project Grant R01AI186812

Award Date 8/1/24
Completion Date 6/30/29
Dollars Obligated $1.5M
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Atlanta, GA 30303, USA
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This $1,501,625 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports the development of broadly neutralizing nanobodies for advancing AIDS therapy. The primary objectives are to:

  1. Identify versatile nanobodies capable of recognizing various regions of the HIV envelope protein through advanced phage-display screening.
  2. Conduct comprehensive characterization, including neutralization studies, bioinformatic, and structural analyses, to understand the mechanisms of these nanobodies.
  3. Enhance the efficacy of the nanobodies by leveraging structural insights for rational design to broaden their targeting capabilities.

The awardee, Georgia State University Research Foundation Inc., will collaborate with a sub-awardee, The Ohio State University, to generate stabilized HIV envelope antigens, perform structural analyses, and engineer optimized nanobody/antibody molecules targeting multiple HIV vulnerability sites. This innovative approach aims to overcome limitations of traditional broadly neutralizing antibodies and advance HIV treatment strategies.

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