Project Grant R21AI182913
- This federal Project Grant award in the amount of $850,491.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Icahn School of Medicine at Mount Sinai. The grant supports a research project to conduct an in-depth characterization of myeloid cells in human milk from both HIV-positive and HIV-negative donors. The goal is to investigate the potential role of these milk cells as...
- The Salk Institute for Biological Studies received a $562,500 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the functions of specialized intestinal T cells, called intraepithelial lymphocytes (IELs), that are recruited to the mammary gland during lactogenesis. The central hypothesis is that these entero-mammary IELs promote maternal-offspring immunity by regulating...
- This federal Project Grant award of $4,630,686 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to develop an effective HIV vaccine. The primary goal is to stimulate B cell lineages capable of producing broadly neutralizing antibodies (bnAbs) against diverse HIV strains, a key challenge in traditional vaccine approaches. The research involves preclinical studies in non-human primates using the BG505...
- This $4,686,370.00 Project Grant was awarded on September 25, 2025 by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The grant will fund research to leverage novel pediatric simian/human immunodeficiency virus (SHIV) models to identify biomarkers that predict the efficacy of broadly neutralizing antibodies (bNAbs) in preventing breast milk HIV transmission. The goal is to advance the...
- This $114,976 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will support research conducted by Seattle Children's Research Institute to elucidate the function of T cells present in breastmilk and their potential role in protecting infants against respiratory infections. The key objectives are to: 1) investigate the transcriptional and clonal overlap between T cells in the lactating breast and upper...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $929,500 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Icahn School of Medicine at Mount Sinai (ISMMS) on July 23, 2025. The grant supports research to investigate the mechanism of action of different vaccine platforms, including mRNA-based and Newcastle Disease Virus (NDV)-based vaccines, in inducing long-lasting protective systemic and mucosal immune responses against...
- This federal Project Grant award of $190,944, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program, supports research to investigate the dynamics and formation of B cell immune memory in human vaccination. The research aims to systematically analyze human B cell, plasma cell, and antibody responses after HIV vaccination, and to dissect the mechanisms by which novel vaccine adjuvants like 3M-052-AF...
- This Project Grant award of $797,735 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research CFDA program, aims to elucidate the innate and adaptive immune mechanisms governing neonatal immune responses and sterile inflammation in early life. The research project will utilize a novel mouse model of allergen-induced neonatal sterile inflammation to investigate heightened innate and adaptive immune responses in neonates compared to...
- This $554,786 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to determine the mechanisms by which the probiotic Lactobacillus rhamnosus (LGG) can improve survival of neonatal mice infected with influenza virus. The goal is to understand how LGG impacts the function of pulmonary epithelial cells, the target of influenza infection, as well as innate immune...
- This $108,273 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), supports research to understand the role of mucosal immunity in protecting against SARS-CoV-2 infection and transmission. The central hypothesis is that respiratory IgA antibodies provide neutralization and protection against heterologous infection, facilitated by an interaction between macrophages, CD4 T...
This federal Project Grant award for $477,406.00, awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research), will fund research to verify the use of pigs as an appropriate model for developing human vaccines that target the entero-mammary pathway to elicit a robust secretory IgA (sIgA) immune response in human milk. The research aims to understand the critical role of sIgA in protecting mucosal surfaces, including in breastfed infants, and to inform the design of vaccines that can effectively elicit potent, specific sIgA responses in human milk. The award period is from September 3, 2025 to August 31, 2027, and the research will be conducted by the Icahn School of Medicine at Mount Sinai, a leading academic medical and research institution.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $477.4k | 9/3/25 |