Project Grant K99AI185149
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1,379,954 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Scripps Research Institute. The grant, awarded on August 21, 2025, supports research to engineer durable immunity by optimizing HIV vaccine parameters to drive long-lived plasma cell development. The project aims to systematically study the effects of immunogen affinity, valency, adjuvants, vaccine platforms, and...
- This federal Project Grant award of $4,630,686 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to develop an effective HIV vaccine. The primary goal is to stimulate B cell lineages capable of producing broadly neutralizing antibodies (bnAbs) against diverse HIV strains, a key challenge in traditional vaccine approaches. The research involves preclinical studies in non-human primates using the BG505...
- This Project Grant, awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), provides $1,285,304 to the Scripps Research Institute to conduct research on developing a durable broadly neutralizing antibody (bnAb) response for an HIV vaccine. The key objectives are to: Assess the durability of a 6-shot sequential vaccine regimen that induces bnAb responses in non-human primates. Evaluate the...
- This Cooperative Agreement award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), aims to define the molecular determinants of durable versus non-durable antibody responses in vaccinated individuals. The $777,495 award will fund a 5-year clinical trial to characterize antibody-secreting cell populations and their antibody production over time in response to vaccines that induce...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $108,486 to the Scripps Research Institute to develop soluble and membrane-bound immunogens that can shepherd the maturation of broadly neutralizing antibodies (bnAbs) targeting the highly conserved membrane proximal external region (MPER) of the HIV-1 envelope protein. The goal is to advance the quest for a...
- This federal Project Grant award for $711,993.00, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research to examine the effects of Mycobacterium tuberculosis (MTB) disease on HIV-1 pathogenesis in people living with HIV (PWH). The research aims to assess how MTB disease influences the development of broadly neutralizing HIV-1 antibodies, the emergence of NAb-resistant viral...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $483,825 to Yale University to elucidate how broadly neutralizing antibodies (bNAbs) targeting the membrane-proximal external region (MPER) of the HIV-1 envelope glycoprotein (Env) engage with native virus particles and interfere with virus-host membrane fusion. The study will utilize cryo-electron tomography...
- This federal Project Grant award, valued at $735,078 and awarded on May 1, 2025, is provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program. The grant aims to unravel the molecular mechanisms of innate immune memory in humans, examining the epigenetic determinants that induce long-lasting "trained immunity" in human myeloid and lymphoid progenitor cells. Using single-cell gene expression...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to define the role of the NF-κB signaling network in regulating affinity maturation and the generation of plasma cells versus memory B cells. The $625,348 grant, awarded to the University of Utah, aims to elucidate how the NF-κB regulators IκBα and IκBε control the differentiation of germinal center B cells into long-lived plasma cells...
- This $451,000.00 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research (CFDA 93.855) federal grant program, supports research to investigate the manipulation of antibody responses by a retrovirus. The research aims to enhance understanding of how pathogens can directly or indirectly modulate B cells, which play a critical role in providing long-term protective immunity. Specifically, the study will examine...
This federal Project Grant award of $190,944, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program, supports research to investigate the dynamics and formation of B cell immune memory in human vaccination. The research aims to systematically analyze human B cell, plasma cell, and antibody responses after HIV vaccination, and to dissect the mechanisms by which novel vaccine adjuvants like 3M-052-AF can enhance the durability and breadth of protective antibody responses. The project will leverage the awardee's expertise in human B cell biology, vaccinology, and systems immunology tools to identify vaccine-responsive B cell populations that are clonally related to long-lived memory B and plasma cells, and to evaluate how adjuvants modulate B cell differentiation pathways. The award has a performance period from August 8, 2025 to July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $190.9k | 8/8/25 |