Project Grant R01AI182586
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $562,500 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Salk Institute for Biological Studies. The 5-year grant, awarded on Jul 23, 2025, will fund research to investigate the functions of specialized intestinal T cells, called intraepithelial lymphocytes (IELs), that are recruited to the mammary gland during lactogenesis. The research aims to elucidate how these IELs...
- This $4,686,370.00 Project Grant award was made by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program. The grant supports research to leverage novel pediatric simian/human immunodeficiency viruses (SHIVs) to identify biomarkers that can predict the protective efficacy of broadly neutralizing antibodies (bNAbs) against HIV transmission through breast milk. The research, conducted by Weill Medical College of...
- This $477,406 Project Grant was awarded on September 3, 2025 by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research to verify the use of pigs as an appropriate model for developing human vaccines that target the entero-mammary pathway to elicit a robust secretory IgA response in human breast milk. This research aims to address the critical need to design vaccines capable of...
- The National Institute of Allergy and Infectious Diseases (NIAID) has awarded a $781,367 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Weill Medical College of Cornell University. The grant, awarded on January 25, 2024, will support research to define and maximize the impact of CD8+ T-cell selection on the landscape of HIV integration sites. The goal is to optimize strategies for eradicating the persistent reservoir of HIV-infected cells and achieve...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $170,411 Project Grant under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) to Brigham & Women's Hospital Inc. The grant, awarded on August 8, 2025, will provide mentorship to trainees and early career investigators in clinical studies and translational virology techniques related to HIV persistence, therapeutic interventions for sustained antiretroviral therapy-free HIV...
- This $114,976 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will support research conducted by Seattle Children's Research Institute to elucidate the function of T cells present in breastmilk and their potential role in protecting infants against respiratory infections. The key objectives are to: 1) investigate the transcriptional and clonal overlap between T cells in the lactating breast and upper...
- This federal Project Grant award was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The $797,735 award supports research to elucidate the innate and adaptive mechanisms governing neonatal immune responses and investigate how the innate immune system detects and mediates sterile inflammation during early life development. The grant recipient, the Icahn School of Medicine at Mount Sinai, is...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $859,992 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Yale University. The grant supports research on the molecular mechanisms underlying HIV-1 maturation and the effects of inhibitor compounds on this process. The research involves using advanced in situ cryo-electron microscopy techniques to visualize the structural transitions of HIV-1 Gag assemblies and capsid during...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $214,996 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Oregon Health & Science University (OHSU). The award, effective from September 1, 2025 to August 31, 2028, will support research to improve antibody responses in infants with HIV-1 by targeting the differentiation of T follicular helper (Tfh) cells. The goal is to increase the magnitude and durability of antibody...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $3,021,038 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the Icahn School of Medicine at Mount Sinai to conduct research on the role of the chemokine receptor CCR5 in maternal flavivirus infections. The research aims to unravel the mechanisms involved in CCR5-mediated protection during maternal infections by flaviviruses like Zika virus, West Nile virus, and other neurotropic flaviviruses....
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $850,491 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Icahn School of Medicine at Mount Sinai. The grant will fund a research project to conduct an in-depth characterization of myeloid cells in human breast milk from both HIV-positive and HIV-negative donors. The goal is to understand the potential role of these milk cells in either transmitting or defending against vertical transmission of HIV through breastfeeding. The project aims to classify and compare the milk myeloid cells across lactation periods, as well as determine their anti-viral functionality and HIV susceptibility. This research is intended to generate essential data to support the development of targeted therapeutics for reducing vertical HIV transmission during breastfeeding.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $850.5k | 9/19/25 |